3-(benzyloxy)-5-chlorobenzoic acid

Base Information

• Chemical Name: 3-(benzyloxy)-5-chlorobenzoic acid
• CAS No.: 53985-44-7
• Molecular Formula: C₁₄H₁₁ClO₃
• Molecular Weight: 262.693
• Mol file: 53985-44-7.mol

Synonyms:3-(benzyloxy)-5-chlorobenzoic acid

Chemical Property of 3-(benzyloxy)-5-chlorobenzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(benzyloxy)-5-chlorobenzoic acid

There total 6 articles about 3-(benzyloxy)-5-chlorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

carbon dioxide (124-38-9,18923-20-1) + 1-(benzyloxy)-3,5-dichlorobenzene (128924-00-5) → 3-(benzyloxy)-5-chlorobenzoic acid (53985-44-7)

Guidance literature:

1-(benzyloxy)-3,5-dichlorobenzene; With magnesium; methyl iodide; In diethyl ether; for 1h; Heating;

carbon dioxide; In diethyl ether; at 0 ℃; for 1h; Further stages.;

DOI:10.1021/jm010531d

Reference yield:

3-chloro-5-hydroxybenzoic acid (53984-36-4) → 3-(benzyloxy)-5-chlorobenzoic acid (53985-44-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / 6 h / Reflux

2: potassium carbonate / acetone / 2 h / Reflux

3: water; sodium hydroxide / methanol / Reflux

With sulfuric acid; water; potassium carbonate; sodium hydroxide; In methanol; acetone;

Reference yield:

3-chloro-5-benzyloxybenzoic acid benzylester → 3-(benzyloxy)-5-chlorobenzoic acid (53985-44-7)

Guidance literature:

With potassium hydroxide; In methanol; water; at 50 ℃; for 4h;

DOI:10.1002/cmdc.201500545

upstream raw materials:

carbon dioxide

1-(benzyloxy)-3,5-dichlorobenzene

3-chloro-5-hydroxybenzoic acid

methyl 3-chloro-5-hydroxybenzoate

Downstream raw materials:

4-(5-{[(R)-1-(3-Chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-ylamino]-methyl}-imidazol-1-ylmethyl)-2-fluoro-benzonitrile

[1-(3-benzyloxy-5-chloro-benzylcarbamoyl)-3-methylsulfanyl-propyl]-carbamic acid tert-butyl ester

[1-(3-chloro-5-hydroxy-benzyl)-2-oxo-pyrrolidin-3-yl]-carbamic acid tert-butyl ester

1-Azidomethyl-3-benzyloxy-5-chloro-benzene

Refernces

• 1、 Roy, Sudeshna,?ileikyte, Justina,Neuenswander, Benjamin,Hedrick, Michael P.,Chung, Thomas D. Y.,Aubé, Jeffrey,Schoenen, Frank J.,Forte, Michael A.,Bernardi, Paolo. "N-Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore". . p. 283 - 288. Retrieved 2016/02/16.
• 2、 -. "BIARYL-PROPIONIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICALS". . . Retrieved 2014/10/15.