Evernic acid

Base Information

• Chemical Name: Evernic acid
• CAS No.: 537-09-7
• Molecular Formula: C17H16 O7
• Molecular Weight: 332.31
• Hs Code.: 2918990090
• European Community (EC) Number: 208-658-2
• NSC Number: 81164
• UNII: 2EQ5W5403J
• DSSTox Substance ID: DTXSID20201956
• Nikkaji Number: J13.675A
• Wikipedia: Evernic_acid
• Wikidata: Q27190901
• Metabolomics Workbench ID: 123535
• ChEMBL ID: CHEMBL1484978
• Mol file: 537-09-7.mol

Synonyms:evernic acid;evernic acid, monopotassium salt

Chemical Property of Evernic acid

Chemical Property:

• Vapor Pressure: 2.93E-05mmHg at 25°C
• Melting Point: 166-167°C
• Boiling Point: 531.8°Cat760mmHg
• Flash Point: 194.6°C
• PSA: 113.29000
• Density: 1.391g/cm³
• LogP: 2.64060
• XLogP3: 4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 332.08960285
• Heavy Atom Count: 24
• Complexity: 466

Purity/Quality:

98%,99%, ^*data from raw suppliers

EvernicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CC(=C1C(=O)OC2=CC(=C(C(=C2)C)C(=O)O)O)O)OC
• Description: Evernic acid is a secondary metabolite produced by some species of lichen that can bind to allosteric sites on the protein surface of FAS-II enzymes and produce antibacterial and antiplasmodial effects. It inhibits two key plasmodial FAS-II enzymes PfFabZ and PfFabI (IC50 = 10.7 and 36.1 μM, respectively) but shows low efficacy against the malaria parasite P. berghei (IC50 = 77.3 μM).

Technology Process of Evernic acid

There total 2 articles about Evernic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ evernic acid (537-09-7)

Guidance literature:

With sodium hydroxide;

Reference yield:

→ evernic acid (537-09-7)

Guidance literature:

Mycelium, H2O2;

DOI:10.1016/S0031-9422(00)86530-9

Reference yield: 10.0%

evernic acid (537-09-7) + 4-Hydroxy-2-methoxy-6-methylbenzoesaeure-methylester (3465-63-2) → 2-O-methyltenuiorin (80144-98-5)

Guidance literature:

With trifluoroacetic anhydride; In toluene; for 2h; Ambient temperature;

Downstream raw materials:

Evernsaeuremethylester

2-hydroxy-4-(2-hydroxy-4-methoxy-6-methyl-benzoyloxy)-6-methyl-benzoic acid ethyl ester

ethyl everninate

2-hydroxy-4-methoxy-6-methyl-benzoic acid methyl ester