4-Amino-3-hydroxybenzoic acid

Base Information

• Chemical Name: 4-Amino-3-hydroxybenzoic acid
• CAS No.: 2374-03-0
• Molecular Formula: C7H7NO3
• Molecular Weight: 153.137
• Hs Code.: 29225090
• Mol file: 2374-03-0.mol

Synonyms:(4-Carboxy-2-hydroxyphenyl)amine;3-Hydroxy-4-aminobenzoic acid;3-Hydroxy-PABA;3-Hydroxy-p-aminobenzoic acid;NSC 407243;

Chemical Property of 4-Amino-3-hydroxybenzoic acid

Chemical Property:

• Appearance/Colour: yellow-brown to brown crystalline powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 211-215 °C(lit.)
• Refractive Index: 1.691
• Boiling Point: 385.7 °C at 760 mmHg
• PKA: 4.74±0.10(Predicted)
• Flash Point: 187.1 °C
• PSA: 83.55000
• Density: 1.492 g/cm³
• LogP: 1.25380
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Water Solubility.: Soluble in chloroform, and aqeous ethanol, water (Partly miscible)

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-3-hydroxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Amino-3-hydroxybenzoic Acid is disubsituted benzoic acid used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors. 4-Amino-3-hydroxybenzoic acid is used in the preparation of various pharmaceutical compounds such as sphingosine kinase inhibitors.

Technology Process of 4-Amino-3-hydroxybenzoic acid

There total 6 articles about 4-Amino-3-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-4-nitro-benzoic acid (619-14-7) → 4-aminosalicylic acid (2374-03-0)

Guidance literature:

With hydrogenchloride; tin;

Reference yield:

3-Carboxyphenol (99-06-9) → 4-aminosalicylic acid (2374-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate / acetonitrile / 20 °C

2: hydrogen; palladium on activated charcoal / methanol / 20 °C

With ammonium cerium (IV) nitrate; palladium on activated charcoal; hydrogen; In methanol; acetonitrile;

Reference yield:

→ 4-aminosalicylic acid (2374-03-0)

Guidance literature:

With water; sodium acetate; im Rohr;

upstream raw materials:

3-hydroxy-4-nitro-benzoic acid

4-amino-benzoic acid

3-Carboxyphenol

Downstream raw materials:

4-ethoxycarbonylamino-3-hydroxy-benzoic acid

3-hydroxy-4-aminobenzoic acid methyl ester

ethyl 4-amino-3-hydroxybenzoate

3-hydroxy-4-ureido-benzoic acid

Refernces

• 1、 -. "Amino-benzoic acids and derivatives, and methods of use". . . Retrieved 2008/06/13.
• 2、 Stutts, K. J.,Scortichini, C. L.,Repucci, C. M.. "Electrochemical Reduction of Nitroaromatics to Anilines in Basic Media: Effects of Positional Isomerism and Cathode Composition". . p. 3740 - 3744. Retrieved 2007/10/02.