Technology Process of (4R)-4-[(benzyloxy)methyl]-2,2-dimethyl-5-methylene-1,3-dioxane
There total 4 articles about (4R)-4-[(benzyloxy)methyl]-2,2-dimethyl-5-methylene-1,3-dioxane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Methyltriphenylphosphonium bromide;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 2h;
(4S)-4-[(benzyloxy)methyl]-2,2-dimethyl-1,3-dioxan-5-one;
In
tetrahydrofuran;
for 3h;
Further stages.;
DOI:10.1055/s-2007-965967
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 0.64 g / aq. oxalic acid / diethyl ether / 2 h / 20 °C
2.1: t-BuOK / tetrahydrofuran / 2 h / 0 °C
2.2: 83 percent / tetrahydrofuran / 3 h
With
potassium tert-butylate; oxalic acid;
In
tetrahydrofuran; diethyl ether;
2.2: Wittig olefination;
DOI:10.1055/s-2007-965967
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tert-butyllithium / tetrahydrofuran; pentane / 2 h / -78 °C
1.2: tetrahydrofuran; pentane / -100 - 20 °C
2.1: 0.64 g / aq. oxalic acid / diethyl ether / 2 h / 20 °C
3.1: t-BuOK / tetrahydrofuran / 2 h / 0 °C
3.2: 83 percent / tetrahydrofuran / 3 h
With
potassium tert-butylate; tert.-butyl lithium; oxalic acid;
In
tetrahydrofuran; diethyl ether; pentane;
3.2: Wittig olefination;
DOI:10.1055/s-2007-965967