Multi-step reaction with 8 steps
1: 82 percent / barium oxide, barium hydroxide octahydrate / dimethylformamide / 2 h / Ambient temperature; 1.) N,N-dimethylformamide, RT, 2 h, 2.) chloroform, reflux, 2 h
2: 78 percent / 60 percent aq. acetic acid / 2 h / 90 - 95 °C
3: 84 percent / pyridine / 30 h / Ambient temperature
4: 89 percent / NaOH / dimethylformamide / 5 h / Ambient temperature
5: 79 percent / 60 percent aq. acetic acid / 2 h / 90 °C
6: 56 percent / KOH / benzene; dimethylformamide / 3 h / Ambient temperature
7: 1.) NaBH4, 2.) dicyclohexylcarbondiimide / 1.) DMF, 6 h, 0 deg C, 2.) CH2Cl2, RT, 16 h
8: 68 percent / 1,4-diazabicyclo<2.2.2>octane, tris(triphenylphosphine)rhodium chloride / methanol / 5 h / Heating
With
pyridine; 1,4-diaza-bicyclo[2.2.2]octane; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; Wilkinson's catalyst; barium hydroxide octahydrate; acetic acid; dicyclohexyl-carbodiimide; barium(II) oxide;
In
methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1246/bcsj.54.3570