Pandacostat

Base Information

• Chemical Name: Pandacostat
• CAS No.: 1224158-00-2
• Molecular Formula: C₁₇H₁₅N₃O₆
• Molecular Weight: 357.323
• Mol file: 1224158-00-2.mol

Synonyms:Pandacostat

Chemical Property of Pandacostat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Pandacostat

There total 7 articles about Pandacostat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(E)-3-(4-(hydrazinecarbonyl)phenyl)-N-hydroxyacrylamide (1223593-76-7) + 2,3,4-trihydroxybenzylaldehyde (2144-08-3) → Pandacostat (1224158-00-2)

Guidance literature:

In dimethyl sulfoxide; at 70 ℃; for 16h;

Reference yield:

4-Carboxybenzaldehyde (619-66-9) → Pandacostat (1224158-00-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: piperidine / pyridine / 18 h / 100 °C / Inert atmosphere

1.2: 0 °C

2.1: triethylamine; methyl chloroformate / dichloromethane / 1 h / 0 °C

3.1: dmap / dichloromethane / 3 h / 20 °C

4.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; methanol / 18 h

5.1: hydrogenchloride / methanol / 1 h / 20 °C

6.1: sodium hydroxide / water / pH 11

7.1: dimethyl sulfoxide / 16 h / 70 °C

With piperidine; hydrogenchloride; hydroxylamine hydrochloride; triethylamine; methyl chloroformate; sodium hydroxide; dmap; In pyridine; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

(E)-ethyl 3-(4-(hydrazinecarbonyl)phenyl)acrylate (1223593-69-8) → Pandacostat (1224158-00-2)

Guidance literature:

Multi-step reaction with 5 steps

1: dmap / dichloromethane / 3 h / 20 °C

2: hydroxylamine hydrochloride; sodium hydroxide / ethanol; methanol / 18 h

3: hydrogenchloride / methanol / 1 h / 20 °C

4: sodium hydroxide / water / pH 11

5: dimethyl sulfoxide / 16 h / 70 °C

With hydrogenchloride; hydroxylamine hydrochloride; sodium hydroxide; dmap; In methanol; ethanol; dichloromethane; water; dimethyl sulfoxide;

upstream raw materials:

4-Carboxybenzaldehyde

ethyl (E)-3-[4-(hydroxycarbonyl)phenyl]prop-2-enoate

(E)-3-(4-(hydrazinecarbonyl)phenyl)-N-hydroxyacrylamide

2,3,4-trihydroxybenzylaldehyde

Refernces