2-Aminoacridine

Base Information

• Chemical Name: 2-Aminoacridine
• CAS No.: 581-28-2
• Molecular Formula: C13H10 N2
• Molecular Weight: 194.236
• Hs Code.: 2933990090
• UNII: FZ24NE6LYA
• DSSTox Substance ID: DTXSID50206818
• Nikkaji Number: J55.079E
• Wikipedia: 2-Aminoacridine
• Wikidata: Q4596858
• ChEMBL ID: CHEMBL146566
• Mol file: 581-28-2.mol

Synonyms:Acridin-2-amine;2-Aminoacridine;581-28-2;2-Acridinamine;ACRIDINE, 2-AMINO-;2-Aminoakridin [Czech];2-Aminoakridin;3-Aminoacridine (European);CCRIS 2106;2-Acridinamine (9CI);FZ24NE6LYA;BRN 0142309;5-22-11-00005 (Beilstein Handbook Reference);2-Amino-acridin;Acridin-2-ylamine;UNII-FZ24NE6LYA;CHEMBL146566;SCHEMBL1230201;DTXSID50206818;MFCD00458208;AKOS006275533;DS-4118;CS-0155659;FT-0691525;C75723;A869522;Q4596858

Chemical Property of 2-Aminoacridine

Chemical Property:

• Vapor Pressure: 1.81E-07mmHg at 25°C
• Melting Point: 218ºC
• Refractive Index: 1.78
• Boiling Point: 426.2 °C at 760 mmHg
• PKA: pKa -1.4(H2O T=room temperature(RT) Iunspeci?ed) (Uncertain);8.0(H2O T=room temperature(RT) Iunspeci?ed) (Uncertain);1.1 (H2O t=RT Iunspecified) (Uncertain);5.9 (H2O t=RT Iunspecified) (Uncertain)
• Flash Point: 241.2 °C
• PSA: 38.91000
• Density: 1.268 g/cm³
• LogP: 3.55140
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: 9.712mg/L(24 oC)
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 194.084398327
• Heavy Atom Count: 15
• Complexity: 229

Purity/Quality:

99% ^*data from raw suppliers

Acridin-2-amine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C3C=C(C=CC3=N2)N

Technology Process of 2-Aminoacridine

There total 11 articles about 2-Aminoacridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-aminoacridone (27918-14-5) → 2-aminoacridine (581-28-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol

2: POCl₃

3: toluene-4-sulfonic acid hydrazide; HCl; CHCl₃ / anschl. mit wss. NaOH und Glykol

With hydrogenchloride; ethanol; chloroform; toluene-4-sulfonic acid hydrazide; trichlorophosphate;

DOI:10.1039/jr9490001148

Reference yield:

2-nitroacridone (7251-00-5) → 2-aminoacridine (581-28-2)

Guidance literature:

With sodium hydroxide; ethanol; und amalgamiertes Aluminium und anschl. Erwaermen mit FeCl₃ und wss. HCl;

Reference yield:

2-Nitroacridine (29808-81-9) → 2-aminoacridine (581-28-2)

Guidance literature:

With hydrogenchloride; tin;

upstream raw materials:

2-Nitroacridine

2-nitroacridone

9-chloro-2-urethano-acridine

ethanol

Downstream raw materials:

acridin-2-ol

2-Acetamino-acridin

Refernces