Technology Process of 1-benzyl-4-benzyloxy-3-(4-methoxyphenyl)pyridin-2(1H)-one
There total 4 articles about 1-benzyl-4-benzyloxy-3-(4-methoxyphenyl)pyridin-2(1H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
5% Pd/C; sodium carbonate;
In
water; isopropyl alcohol;
at 60 ℃;
for 12h;
DOI:10.1002/ejoc.201200721
- Guidance literature:
-
Multi-step reaction with 4 steps
1: bromine; hydrogen bromide; acetic acid / water / 0.5 h / 0 °C
2: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
3: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 4 h / 20 °C
4: 5% Pd/C; sodium carbonate / water; isopropyl alcohol / 12 h / 60 °C
With
N-iodo-succinimide; 5% Pd/C; hydrogen bromide; bromine; sodium carbonate; potassium carbonate; acetic acid; trifluoroacetic acid;
In
water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
4: |Suzuki-Miyaura Coupling;
DOI:10.1002/ejoc.201200721
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C
2: N-iodo-succinimide; trifluoroacetic acid / acetonitrile / 4 h / 20 °C
3: 5% Pd/C; sodium carbonate / water; isopropyl alcohol / 12 h / 60 °C
With
N-iodo-succinimide; 5% Pd/C; sodium carbonate; potassium carbonate; trifluoroacetic acid;
In
water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
3: |Suzuki-Miyaura Coupling;
DOI:10.1002/ejoc.201200721