Technology Process of 3-(3-(4-hydroxyphenoxy)-2,4-diiodophenyl)propanoic acid
There total 5 articles about 3-(3-(4-hydroxyphenoxy)-2,4-diiodophenyl)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron tribromide;
In
dichloromethane;
at -78 - 20 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: iodine; dihydrogen peroxide / water / 24 h / 50 °C
2: dichloromethane
3: sodium tetrahydroborate; nickel(II) chloride hexahydrate; ethanol / tetrahydrofuran / 1.17 h / 0 - 20 °C
4: pyridine; copper diacetate; triethylamine / dichloromethane / 72 h / Molecular sieve
5: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
With
pyridine; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ethanol; dihydrogen peroxide; iodine; copper diacetate; boron tribromide; triethylamine;
In
tetrahydrofuran; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: dichloromethane
2: sodium tetrahydroborate; nickel(II) chloride hexahydrate; ethanol / tetrahydrofuran / 1.17 h / 0 - 20 °C
3: pyridine; copper diacetate; triethylamine / dichloromethane / 72 h / Molecular sieve
4: boron tribromide / dichloromethane / -78 - 20 °C / Inert atmosphere
With
pyridine; sodium tetrahydroborate; nickel(II) chloride hexahydrate; ethanol; copper diacetate; boron tribromide; triethylamine;
In
tetrahydrofuran; dichloromethane;