Technology Process of C26H33ClN7O5P
There total 7 articles about C26H33ClN7O5P which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-(4-methylpiperazinyl)ethanol;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 0.333333h;
Microwave irradiation;
(2-((5-chloro-2-((4-fluoro-2-methoxy-5-nitrophenyl)amino)pyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide;
In
tetrahydrofuran; mineral oil;
at 67 ℃;
for 25h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium phosphate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / N,N-dimethyl-formamide / 3 h / 150 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C
3.1: trifluoroacetic acid / iso-butanol / 100 °C / Sealed tube
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C / Microwave irradiation
4.2: 25 h / 67 °C / Sealed tube
With
potassium phosphate; sodium hydride; potassium carbonate; trifluoroacetic acid;
palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene;
In
tetrahydrofuran; N,N-dimethyl-formamide; iso-butanol; mineral oil;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: ammonium chloride / zinc / water; acetone / 0 - 20 °C
2.1: sulfuric acid; guanidine nitrate / 0.5 h / Cooling with ice
3.1: trifluoroacetic acid / iso-butanol / 100 °C / Sealed tube
4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 20 °C / Microwave irradiation
4.2: 25 h / 67 °C / Sealed tube
With
sulfuric acid; guanidine nitrate; sodium hydride; ammonium chloride; trifluoroacetic acid;
zinc;
In
tetrahydrofuran; water; acetone; iso-butanol; mineral oil;