2,4,5-Trifluorobenzoyl chloride

Base Information

• Chemical Name: 2,4,5-Trifluorobenzoyl chloride
• CAS No.: 88419-56-1
• Molecular Formula: C7H2ClF3O
• Molecular Weight: 194.54
• Hs Code.: 29163990
• Mol file: 88419-56-1.mol

Synonyms:2,4,5-tifluorobenzoylchloride;2,3-DIHYDRO-2,2-DIMETHYL-7-HYDROXYBENZOFURAN;2,4,5-trifluorobenzoic acid chloride;2,4,5-trifluoro-benzoyl chloride;2,4,5-Trifluorobenzoyl;

Chemical Property of 2,4,5-Trifluorobenzoyl chloride

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 1.25mmHg at 25°C
• Refractive Index: n20/D 1.498(lit.)
• Boiling Point: 173.7 °C at 760 mmHg
• Flash Point: 58.9 °C
• PSA: 17.07000
• Density: 1.514 g/cm³
• LogP: 2.48290
• Sensitive.: Lachrymatory

Purity/Quality:

98% ^*data from raw suppliers

2,4,5-Trifluorobenzoyl Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45-25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2,4,5-Trifluorobenzoyl chloride

There total 10 articles about 2,4,5-Trifluorobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2,4,5-trifluorobenzoic acid (446-17-3) → 2,4,5-trifluorobenzoyl chloride (88419-56-1)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.0c00196

Reference yield:

oxalyl dichloride (79-37-8) + 2,4,5-trifluorobenzoic acid (446-17-3) → 2,4,5-trifluorobenzoyl chloride (88419-56-1)

Guidance literature:

With N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 24h;

Reference yield:

1-bromo-2,4,5-trifluorobenzene (327-52-6) → 2,4,5-trifluorobenzoyl chloride (88419-56-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylformamide / 17 h / Heating

2: aq. H₂SO₄ / 2 h / Heating

3: (COCl)2, DMF / CH₂Cl₂

With oxalyl dichloride; sulfuric acid; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00400a016

upstream raw materials:

2,4,5-trifluorobenzoic acid

1-bromo-2,4,5-trifluorobenzene

2,4,5-trifluorobenzonitrile

1,2,4-trifluorobenzene

Downstream raw materials:

phenyl 2,4,5-trifluorobenzoate

ethyl 2,4,5-trifluorobenzoylacetate

1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylate ethyl ester

ciprofloxacin hydrochloride

Refernces

• 1、 . "-". . . Retrieved 2020.
• 2、 Alonso-Martínez, Francisco-Javier,Benito-Lama, Miguel,Dobiasová, Simona,Domínguez-álvarez, Enrique,Habibullah, Giyaullah,Kincses, Annamária,Nové, Márta,Salardón-Jiménez, Noemi,Sevilla-Hernández, Clotilde,Spengler, Gabriella,Szemerédi, Nikoletta,Viktorová, Jitka. "Cyano-and ketone-containing selenoesters as multi-target compounds against resistant cancers". . . Retrieved 2021/09/13.
• 3、 -. "Refining method of ciprofloxacin and meglumine hydrochloride thereof". Paragraph 0026-0028. . Retrieved 2021/10/27.