Multi-step reaction with 8 steps
1.1: n-butyllithium / N,N-dimethyl-formamide / 0.75 h / -78 °C
1.2: -78 - 0 °C
1.3: 0 °C
2.1: potassium phosphate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 10 h / 90 °C
3.1: potassium phosphate monohydrate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 16 h / 90 °C
4.1: hydrogen / H-Cube / methanol / 40 °C / 7500.75 Torr
5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1 h / 60 °C
6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C
7.1: carbon tetrabromide; triphenylphosphine / 1,2-dichloro-ethane / 16 h / 20 °C
8.1: potassium carbonate / acetone / 2 h / 50 °C
With
potassium phosphate; n-butyllithium; potassium phosphate monohydrate; carbon tetrabromide; water; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; sodium hydroxide;
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone;