2-ethoxy-6-(2-methylphenyl)napthalene

Base Information

• Chemical Name: 2-ethoxy-6-(2-methylphenyl)napthalene
• CAS No.: 1377784-77-4
• Molecular Formula: C₁₉H₁₈O
• Molecular Weight: 262.351
• Mol file: 1377784-77-4.mol

Synonyms:2-ethoxy-6-(2-methylphenyl)napthalene

Chemical Property of 2-ethoxy-6-(2-methylphenyl)napthalene

Chemical Property:

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Technology Process of 2-ethoxy-6-(2-methylphenyl)napthalene

There total 1 articles about 2-ethoxy-6-(2-methylphenyl)napthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2-ethoxy-6-bromo-naphthalene (66217-19-4) + 2-Methylphenylboronic acid (16419-60-6) → 2-ethoxy-6-(2-methylphenyl)napthalene (1377784-77-4)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In toluene; at 80 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201201153

Reference yield: 89.0%

2-ethoxy-6-(2-methylphenyl)napthalene (1377784-77-4) → (-)-2-ethoxy-6-(2-methylphenyl)-1,2,3,4-tetrahydronaphthalene

Guidance literature:

With hydrogen; N,N,N',N'-tetramethylguanidine; In isopropyl alcohol; at 100 ℃; for 48h; under 38002.6 Torr; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201201153

upstream raw materials:

2-ethoxy-6-bromo-naphthalene

2-Methylphenylboronic acid

Refernces