1-CHLOROCARBONYLOXYADAMANTANE

Base Information

• Chemical Name: 1-CHLOROCARBONYLOXYADAMANTANE
• CAS No.: 5854-52-4
• Molecular Formula: C11H15 Cl O2
• Molecular Weight: 214.692
• Mol file: 5854-52-4.mol

Synonyms:Formicacid, chloro-, 1-adamantyl ester (7CI,8CI); 1-Adamantanol, chloroformate;1-Adamantyl chloroformate; Adamantyl chloroformate; Adamantyloxycarbonylchloride; Chloroformic acid 1-adamantyl ester; NSC 151032

Chemical Property of 1-CHLOROCARBONYLOXYADAMANTANE

Chemical Property:

• Vapor Pressure: 0.00663mmHg at 25°C
• Boiling Point: 271°Cat760mmHg
• Flash Point: 119.4°C
• PSA: 26.30000
• Density: 1.25g/cm³
• LogP: 3.33060

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CHLOROCARBONYLOXYADAMANTANE

There total 3 articles about 1-CHLOROCARBONYLOXYADAMANTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

bis(trichloromethyl) carbonate (32315-10-9) + 1-adamanthanol (768-95-6) → 1-adamantyl chloroformate (5854-52-4)

Guidance literature:

bis(trichloromethyl) carbonate; With pyridine; In toluene; at 0 ℃; for 2h; Inert atmosphere;

1-adamanthanol; In toluene; at 20 ℃; for 24h; Inert atmosphere;

Reference yield: 77.0%

phosgene (75-44-5) + 1-adamanthanol (768-95-6) → 1-adamantyl chloroformate (5854-52-4)

Guidance literature:

With pyridine; In toluene; at 0 - 20 ℃; for 5h;

DOI:10.3891/acta.chem.scand.47-0374

Reference yield:

→ 1-adamantyl chloroformate (5854-52-4)

Guidance literature:

DOI:10.1021/ja01025a030

upstream raw materials:

phosgene

1-adamanthanol

bis(trichloromethyl) carbonate

Downstream raw materials:

N-(1-Adamantyloxycarbonyl)-L-phenylalanin

N^α-Adamantyloxycarbonyl-N^ε-benzyloxycarbonyl-L-lysin

1-adamantyl carbamate

1-Adamantylcarbazat

Refernces

• 1、 Bai, Zibo,Zhang, Heng,Wang, Hao,Yu, Hanrui,Chen, Gong,He, Gang. "Enantioselective Alkylamination of Unactivated Alkenes under Copper Catalysis". supporting information. p. 1195 - 1202. Retrieved 2021/02/05.
• 2、 -. "Disubstituted beta-lactones as inhibitors of N-acylethanolamine acid amidase (NAAA)". Page/Page column 88. . Retrieved 2016/06/28.