o-(p-Nitrophenoxy)anisole

Base Information

• Chemical Name: o-(p-Nitrophenoxy)anisole
• CAS No.: 32795-85-0
• Molecular Formula: C13H11 N O4
• Molecular Weight: 245.235
• Hs Code.: 2909309090
• European Community (EC) Number: 251-224-2
• DSSTox Substance ID: DTXSID30186462
• Nikkaji Number: J308.288A
• Wikidata: Q83057758
• Mol file: 32795-85-0.mol

Synonyms:1-methoxy-2-(4-nitrophenoxy)benzene;32795-85-0;o-(p-Nitrophenoxy)anisole;EINECS 251-224-2;1-(2-methoxyphenoxy)-4-nitrobenzene;2-(p-Nitrophenoxy)anisole;SCHEMBL5082634;DTXSID30186462;AKOS001101385;1-(2-methoxy-phenoxy)-4-nitro-benzene;BS-28484;F79762;Z31211649

Chemical Property of o-(p-Nitrophenoxy)anisole

Chemical Property:

• Vapor Pressure: 7.59E-05mmHg at 25°C
• Melting Point: 101-102 °C
• Boiling Point: 352.9°Cat760mmHg
• Flash Point: 150.8°C
• PSA: 64.28000
• Density: 1.252g/cm³
• LogP: 3.91890
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 245.06880783
• Heavy Atom Count: 18
• Complexity: 271

Purity/Quality:

99% ^*data from raw suppliers

1-Methoxy-2-(4-nitrophenoxy)benzene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OC2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of o-(p-Nitrophenoxy)anisole

There total 26 articles about o-(p-Nitrophenoxy)anisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methoxy-phenol (90-05-1) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 2-methoxyphenyl 4'-nitrophenyl ether (32795-85-0)

Guidance literature:

Reference yield: 99.0%

2-methoxy-phenol (90-05-1) + 4-chlorobenzonitrile (100-00-5) → 2-methoxyphenyl 4'-nitrophenyl ether (32795-85-0)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 0.0833333h; Heating; microwave irradiation;

DOI:10.1055/s-2005-865321

Reference yield: 82.0%

sodium 2-methoxyphenolate (13052-77-2) + 4-chlorobenzonitrile (100-00-5) → 2-methoxyphenyl 4'-nitrophenyl ether (32795-85-0)

Guidance literature:

With copper; In N,N-dimethyl-formamide; for 8h; Heating;

DOI:10.1002/jhet.5570230307

upstream raw materials:

potassium guaiacolate

4-chlorobenzonitrile

4-Fluoronitrobenzene

para-nitrophenyl bromide

Downstream raw materials:

4-bromo-1-methoxy-2-(4-nitro-phenoxy)-benzene

1,2-dibromo-4-methoxy-5-(4-nitro-phenoxy)-benzene

1-methoxy-4-nitro-2-(4-nitro-phenoxy)-benzene

4-(2'-methoxyphenoxy)benzonitrile

Refernces

• 1、 Wu, Fan,Zhu, Kejie,Wu, Guolin,Gao, Yu,Chen, Haijun. "Nickel-Catalyzed C-O Cross-Coupling Reaction at Low Catalytic Loading with Weak Base Participation". supporting information. p. 519 - 522. Retrieved 2020/01/30.
• 2、 -. "AGRICULTURAL CHEMICALS". Page/Page column 56; 94. . Retrieved 2019/08/08.