1-(2-Methoxyphenyl)piperidine

Base Information

• Chemical Name: 1-(2-Methoxyphenyl)piperidine
• CAS No.: 5181-06-6
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Hs Code.: 2933399090
• NSC Number: 28927
• DSSTox Substance ID: DTXSID60282946
• Nikkaji Number: J2.867.219E
• Wikidata: Q82017348
• Mol file: 5181-06-6.mol

Synonyms:1-(2-methoxyphenyl)piperidine;5181-06-6;NSC28927;2-methoxy-phenyl piperidine;SCHEMBL3020451;1-(2-methoxyphenyl)-piperidine;DTXSID60282946;ZJDWMGREEOZXTH-UHFFFAOYSA-N;MFCD20231456;NSC-28927;AKOS015905280;SB41170;BS-28743;CS-0208705;EN300-7384220

Chemical Property of 1-(2-Methoxyphenyl)piperidine

Chemical Property:

• Vapor Pressure: 0.000952mmHg at 25°C
• Boiling Point: 303.1°Cat760mmHg
• Flash Point: 89.4°C
• PSA: 12.47000
• Density: 1.029g/cm³
• LogP: 2.75050
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 191.131014166
• Heavy Atom Count: 14
• Complexity: 166

Purity/Quality:

99%min ^*data from raw suppliers

1-(2-Methoxyphenyl)piperidine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1N2CCCCC2

Technology Process of 1-(2-Methoxyphenyl)piperidine

There total 12 articles about 1-(2-Methoxyphenyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1,5-dibromo-pentane (111-24-0) + 2-methoxy-phenylamine (90-04-0) → 1-(2-methoxy-phenyl)piperidine (5181-06-6)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; for 40h; Reflux;

DOI:10.1021/ol400568u

Reference yield: 84.0%

1 ,5-pentanediol (111-29-5) + 2-methoxy-phenylamine (90-04-0) → 1-(2-methoxy-phenyl)piperidine (5181-06-6)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; In 1,4-dioxane; at 150 ℃; for 5h;

DOI:10.1021/jo00209a004

Reference yield: 83.0%

piperidine (110-89-4) + 2-bromoanisole (578-57-4) → 1-(2-methoxy-phenyl)piperidine (5181-06-6)

Guidance literature:

With copper; caesium carbonate; methyl-alpha-D-glucopyranoside; In water; dimethyl sulfoxide; at 100 ℃; Sealed tube; Green chemistry;

DOI:10.1055/s-0039-1690702

upstream raw materials:

1,5-dibromo-pentane

2-methoxy-phenylamine

piperidine

1,2-dimethoxybenzene

Downstream raw materials:

tert-butyl ((5-((2-(piperidin-1-yl)phenoxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)carbamate

1-(2-(allyloxy)phenyl)piperidine

C₂₀H₂₂N₂O₃

N-[2-(3,4-Dichlorophenyl)-4-[4-(2-methoxyphenyl)piperidino]butyl]-N-methylbenzamide hydrochloride

Refernces

• 1、 Yuan, Chunling,Zhang, Lei,Zhao, Yingdai. "Cu(II)-catalyzed C-N coupling of (hetero)aryl halides and N-Nucleophiles promoted by α-benzoin oxime". . . Retrieved 2019/11/28.
• 2、 Takasu, Noriaki,Oisaki, Kounosuke,Kanai, Motomu. "Iron-catalyzed oxidative C(3)-H functionalization of amines". supporting information. p. 1918 - 1921. Retrieved 2013/06/04.