Technology Process of (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid
There total 11 articles about (S)-2-{4-[2-(2,4-Diamino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
for 5.5h;
Ambient temperature;
DOI:10.1002/jhet.5570260247
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 8.7 percent / dimethylsulfoxide / 0.33 h / Heating
2: 62 percent / 1 N HCl, H2 / 10 percent Pd/C / propan-2-ol; H2O
3: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C
4: 93 percent / 2,5 N NaOH / methanol / 6 h / Ambient temperature
5: 41 percent / (EtO)2P(O)CN, NEt3, N-methylpyrrolidin-2-one / dimethylformamide / 29 h / Ambient temperature
6: 100 percent / 1 N NaOH / methanol / 5.5 h / Ambient temperature
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium hydroxide; diethyl cyanophosphonate; hydrogen; sodium acetate; triethylamine; sodium iodide;
palladium on activated charcoal;
In
methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1002/jhet.5570260247
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 73 percent / POCl3, DMF / 3.5 h / Heating
2: 71 percent / NH2NH2 / H2O; ethanol / 17 h / Ambient temperature
3: 81 percent / 1 N HCl, H2 / 10 percent Pd/C / ethanol
4: 92 percent / H2 / Davison sponge nickel / ethanol; H2O / 22 h
5: 26 percent / NaOAc, NaI / dimethylsulfoxide / 50 h / 70 °C
6: 93 percent / 2,5 N NaOH / methanol / 6 h / Ambient temperature
7: 41 percent / (EtO)2P(O)CN, NEt3, N-methylpyrrolidin-2-one / dimethylformamide / 29 h / Ambient temperature
8: 100 percent / 1 N NaOH / methanol / 5.5 h / Ambient temperature
With
1-methyl-pyrrolidin-2-one; hydrogenchloride; sodium hydroxide; diethyl cyanophosphonate; hydrogen; sodium acetate; triethylamine; N,N-dimethyl-formamide; sodium iodide; hydrazine; trichlorophosphate;
palladium on activated charcoal; Davison sponge nickel;
In
methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570260247