Quinacrine hydrochloride

Base Information

• Chemical Name: Quinacrine hydrochloride
• CAS No.: 69-05-6
• Molecular Formula: C23H30 Cl N3 O . 2 Cl H
• Molecular Weight: 472.886
• European Community (EC) Number: 200-700-8,204-989-1
• NSC Number: 757307,14229
• DSSTox Substance ID: DTXSID40926553
• NCI Thesaurus Code: C67059
• ChEMBL ID: CHEMBL556980
• Mol file: 69-05-6.mol

Synonyms:Acrichine;Atabrine;Atebrin;Dihydrochloride, Quinacrine;Dimesylate, Quinacrine;Hydrochloride, Quinacrine;Mepacrine;Monoacetate, Quinacrine;Monohydrochloride, Quinacrine;Monomesylate, Quinacrine;Quinacrine;Quinacrine Dihydrochloride;Quinacrine Dihydrochloride, Dihydrate;Quinacrine Dihyrochloride, (R)-Isomer;Quinacrine Dihyrochloride, (S)-Isomer;Quinacrine Dimesylate;Quinacrine Hydrochloride;Quinacrine Monoacetate;Quinacrine Monohydrochloride;Quinacrine Monomesylate;Quinacrine, (+-)-Isomer;Quinacrine, (R)-Isomer;Quinacrine, (S)-Isomer

Chemical Property of Quinacrine hydrochloride

Chemical Property:

• Appearance/Colour: yellow crystals or powder
• Melting Point: ca. 248 - 250 C (decomposes)
• Refractive Index: 1.6300 (estimate)
• PKA: pKa -6.3(H2O t undefined I not reported but low) (Uncertain)
• PSA: 37.39000
• Density: 1.2962 (rough estimate)
• LogP: 6.84740
• Storage Temp.: +15C to +30C
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 435.1844180
• Heavy Atom Count: 29
• Complexity: 461

Purity/Quality:

98%,99%, ^*data from raw suppliers

Quinacrine dihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl
• Uses: A non-specific PLA2 inhibitor. and acetylcholine receptor antagonist Quinacrine is a derivative of acridine that is chemically and clinically very similar to 4-aminoquinolines. It was the primary drug for prevention and therapy of malaria during World War II. Today it is rarely used for treating malaria, although it is used to treat amebiasis. Synonyms of this drug are mepacrine, atabrine, acrisuxin, and others. In treating resistant forms of malaria, tetracycline is also used in combination with pyrimethamine, sulfonamides, sulfones, and dapsone, which is widely used for treating leprosy (as a rule, in combination with pyrimethamine). Quinacrine dihydrochloride has been used:in its uptake and accumulation studies in mouse lung slices using fluorescence microscopein the staining of ATP vesicles in mesenchymal stem cells (MSCs)in uptake-release assay for characterization of dense granule functionality of platelets
• Indications: Quinacrine is no longer used extensively as an antimalarial drug and has been largely replaced by the 4- aminoquinolines.
• Clinical Use: Giardiasis Prophylaxis of malaria Tapeworm infections