Sodium;4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid

Base Information

• Chemical Name: Sodium;4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid
• CAS No.: 6640-22-8
• Molecular Formula: C₂₃H₁₄O₆*2Na
• Molecular Weight: 432.34
• NSC Number: 49174
• Mol file: 6640-22-8.mol

Synonyms:sodium;4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid;NSC-49174;HBDVCWCJDFMCPY-UHFFFAOYSA-N;NSC49174;2-Naphthoic acid,4'-methylenebis[3-hydroxy-, disodium salt;2-Naphthalenecarboxylic acid,4'-methylenebis[3-hydroxy-, disodium salt

Chemical Property of Sodium;4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid

Chemical Property:

• Appearance/Colour: pale yellow to yellow powder
• Vapor Pressure: 2.13E-17mmHg at 25°C
• Melting Point: 300 °C
• Boiling Point: 642.7 °C at 760 mmHg
• Flash Point: 356.5 °C
• PSA: 120.72000
• Density: 1.55[at 20℃]
• LogP: 1.72200
• Solubility.: insoluble in EtOH; ≥18 mg/mL in H2O; ≥28.6 mg/mL in DMSO
• Water Solubility.: 43g/L at 20℃
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 411.08445751
• Heavy Atom Count: 30
• Complexity: 569

Purity/Quality:

99.9% ^*data from raw suppliers

Pamoic acid disodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-37/38-41-48
• Safety Statements: 24/25-45-36/37/39-26-22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O.[Na+]
• Uses: Pamoic acid disodium salt, a supposedly inactive component in many formulations of drugs used to modulate release, is a potent agonist of the orphan receptor GPR35. GPR35 is a class A, rhodopsin-like G protein-coupled receptor (GPCR), strongly expressed in the lower intestine and colon, dorsal root ganglia, as well as a variety of immune cells including monocytes and dendritic cells. Targeting GPR35 provides potential therapeutic opportunities in a range of conditions, such as inflammation, pain and cancer.

Technology Process of Sodium;4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid

There total 1 articles about Sodium;4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Pamoic acid (130-85-8) → embonic acid disodium salt (6640-22-8,7681-47-2,15537-67-4)

Guidance literature:

With sodium hydroxide; In water;

Reference yield: 94.3%

embonic acid disodium salt (6640-22-8,7681-47-2,15537-67-4) + levobupivacaine hydrochloride → bis(levobupivacaine) pamoic acid

Guidance literature:

In water; at 60 ℃; for 1.5h; Solvent; Temperature;

Reference yield: 94.2%

phentermine hydrochloride (1197-21-3) + embonic acid disodium salt (6640-22-8,7681-47-2,15537-67-4) → phentermine pamoate

Guidance literature:

With hydrogenchloride; In water; at 20 - 95 ℃; for 4.5h;

upstream raw materials:

Pamoic acid

Downstream raw materials:

imipramine pamoate

Refernces