N-Methyl-2-phenylacetamide

Base Information

• Chemical Name: N-Methyl-2-phenylacetamide
• CAS No.: 6830-82-6
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2924299090
• European Community (EC) Number: 229-908-7
• NSC Number: 54118
• UNII: QYG65AU9E6
• DSSTox Substance ID: DTXSID8064484
• Nikkaji Number: J81.278A
• Wikidata: Q81991594
• Mol file: 6830-82-6.mol

Synonyms:N-Methyl-2-phenylacetamide;6830-82-6;Benzeneacetamide, N-methyl-;N-Methylphenylacetamide;Acetamide, N-methyl-2-phenyl-;N-methyl-2-phenyl-acetamide;QYG65AU9E6;EINECS 229-908-7;NSC 54118;NSC-54118;AI3-03603;NSC54118;N-methyl phenylacetamide;phenylacetic N-methylimide;UNII-QYG65AU9E6;SCHEMBL60236;N-METHYLBENZENEACETAMIDE;DTXSID8064484;MFCD00051354;AKOS002956035;CS-0314622;FT-0680306;3R-1505;J-523649

Chemical Property of N-Methyl-2-phenylacetamide

Chemical Property:

• Vapor Pressure: 0.000167mmHg at 25°C
• Melting Point: 53-58 °C
• Refractive Index: 1.5760 (estimate)
• Boiling Point: 330.3°C at 760 mmHg
• Flash Point: 192.1°C
• PSA: 29.10000
• Density: 1.031g/cm³
• LogP: 1.36600
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 149.084063974
• Heavy Atom Count: 11
• Complexity: 128

Purity/Quality:

98%min ^*data from raw suppliers

N-Methyl-2-phenylacetamide ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)CC1=CC=CC=C1

Technology Process of N-Methyl-2-phenylacetamide

There total 20 articles about N-Methyl-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-phenylpropan-2-one oxime (13213-36-0) → N-methylphenylacetamide (6830-82-6) + N-(phenylmethyl)acetamide (588-46-5)

Guidance literature:

With silica gel; caesium carbonate; N-tosylimidazole; In N,N-dimethyl-formamide; for 2h; Reflux;

DOI:10.1080/10426500903176554

Reference yield: 89.0%

phenylacetic acid (103-82-2) + N,N'-Dimethylurea (96-31-1) → N-methylphenylacetamide (6830-82-6)

Guidance literature:

With magnesium(II) nitrate hexahydrate; In octane; at 130 ℃; for 24h; Reagent/catalyst;

DOI:10.1039/d0sc01317j

Reference yield: 88.0%

N-(4-(dimethylamino)benzyl)-N-methyl-2-phenylacetamide (1469886-90-5) → N-methylphenylacetamide (6830-82-6)

Guidance literature:

With water; trifluoroacetic acid; In acetonitrile; at 100 ℃; for 2h; Sealed tube;

DOI:10.3987/COM-13-12747

upstream raw materials:

N-methyl-α-phenylmalonamic acid

methylamine

phenylacetyl chloride

2-phenyl-acetimidic acid methyl ester

Downstream raw materials:

N-methyl-2-(4-nitrophenyl)acetamide

N-Methyl-N-phenethylamine

methyl nitrate

(2,4-dinitro-phenyl)-acetic acid

Refernces

• 1、 Abe, Manabu,Akita, Munetaka,Chitose, Youhei,Hyodo, Yuki,Koike, Takashi,Takahashi, Keigo,Yoshizawa, Michito. "Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water". supporting information. . Retrieved 2021/10/21.
• 2、 -. "CRBN LIGANDS AND USES THEREOF". Paragraph 00572-00574. . Retrieved 2019/08/20.