2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid

Base Information

• Chemical Name: 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid
• CAS No.: 32595-59-8
• Molecular Formula: C7H9NO3S
• Molecular Weight: 187.219
• Hs Code.: 29349990
• European Community (EC) Number: 251-122-8
• NSC Number: 76232
• DSSTox Substance ID: DTXSID40954316
• Nikkaji Number: J209.342A
• ChEMBL ID: CHEMBL4105620
• Mol file: 32595-59-8.mol

Synonyms:32595-59-8;2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid;2-Thiopheneserine;2-amino-3-hydroxy-3-thiophen-2-ylpropanoic acid;(2RS,3RS)-2-Amino-3-hydroxy-3-(2-thienyl)-propionic acid;3-(2-Thienyl)-L-serine;DL-beta-(2-Thienyl)-serine;beta-(2-Thienyl)serine;H-DL-beta-(2-Thienyl)-DL-Ser-OH;EINECS 251-122-8;NSC 76232;2-Thiophenepropanoic acid, .alpha.-amino-.beta.-hydroxy-;3-thiophen-2-ylserine;NSC76232;.beta.-(2-Thienyl)serine;DL-beta-(2-Thienyl)serine;.beta.-2-Thienyl-DL-serine;2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoicacid;SCHEMBL1066429;CHEMBL4105620;DTXSID40954316;H-DL-beta-(2-Thienyl)-Ser-OH;H-DL--(2-Thienyl)-DL-Ser-OH;MFCD00067304;NSC-76232;AKOS010055340;CS-W016853;HY-W016137;AS-58956;FT-0688913;D97554;EN300-1247815;alpha-Amino-beta-hydroxy-2-thiophenepropionic acid;2-Thiophenepropanoic acid, alpha-amino-beta-hydroxy-;J-018796

Chemical Property of 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid

Chemical Property:

• Appearance/Colour: Crystalline
• Vapor Pressure: 4.89E-08mmHg at 25°C
• Refractive Index: 1.645
• Boiling Point: 426.6 °C at 760 mmHg
• Flash Point: 211.8 °C
• PSA: 111.79000
• Density: 1.495 g/cm³
• LogP: 0.89370
• Storage Temp.: -15°C
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 187.03031432
• Heavy Atom Count: 12
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CSC(=C1)C(C(C(=O)O)N)O

Technology Process of 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid

There total 2 articles about 2-Amino-3-hydroxy-3-(thiophen-2-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

thiophene-2-carbaldehyde (98-03-3) + glycine (56-40-6,18875-39-3,25718-94-9) → 3-(thien-2-yl)-serine (32595-59-8)

Guidance literature:

With sodium hydroxide; Behandeln des Reaktionsprodukts mit wss. Salzsaeure;

Reference yield:

→ 3-(thien-2-yl)-serine (32595-59-8)

Guidance literature:

Benzaldehyd, 1) Glycin/A./KOH, 2) Thiophen-2-carbaldehyd;

DOI:10.1007/BF00843998

upstream raw materials:

thiophene-2-carbaldehyde

glycine