α-phenyl-γ-methylvalerophenone

Base Information

• Chemical Name: α-phenyl-γ-methylvalerophenone
• CAS No.: 20736-42-9
• Molecular Formula: C₁₈H₂₀O
• Molecular Weight: 252.356
• Mol file: 20736-42-9.mol

Synonyms:α-phenyl-γ-methylvalerophenone

Chemical Property of α-phenyl-γ-methylvalerophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-phenyl-γ-methylvalerophenone

There total 7 articles about α-phenyl-γ-methylvalerophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1,1-diphenylprop-2-en-1-ol (3923-51-1) + isobutyraldehyde (78-84-2) → α-phenyl-γ-methylvalerophenone (20736-42-9)

Guidance literature:

With di-tert-butyl peroxide; In benzene; at 120 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.7b01255

Reference yield: 60.0%

1,2-diphenylprop-2-en-1-one (4452-11-3) + isopropyllithium (1888-75-1) → α-phenyl-γ-methylvalerophenone (20736-42-9) + 2,3-diphenyl-4-methyl-1-penten-3-ol (85267-92-1)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -78 ℃; for 2.5h; Yields of byproduct given;

DOI:10.1021/jo00159a009

Reference yield:

→ α-phenyl-γ-methylvalerophenone (20736-42-9)

Guidance literature:

With hydrogenchloride; sodium nitrite; at 0 ℃; dextrorotatory form;

upstream raw materials:

phenyl benzyl ketone

Isobutyl bromide

4-methyl-1,2-diphenylpentane-1,2-diol

1,2-diphenylprop-2-en-1-one

Downstream raw materials:

phenyl benzyl ketone

benzaldehyde

Refernces

• 1、 Padwa, Albert,Kumagai, Tsutomu,Tohidi, Mahrokh. "Studies Dealing with the Cycloreversion Reactions of Phenyl-Substituted 2,3-Diazabicyclohex-2-enes". . p. 1834 - 1840. Retrieved 2007/10/02.