2-Hydroxypromazine

Base Information

• Chemical Name: 2-Hydroxypromazine
• CAS No.: 3926-64-5
• Molecular Formula: C17H20N2OS
• Molecular Weight: 300.425
• Hs Code.: 2934300000
• DSSTox Substance ID: DTXSID70192507
• Nikkaji Number: J117.368E
• Wikidata: Q83065190
• Mol file: 3926-64-5.mol

Synonyms:2-hydroxypromazine;2-OH-PZ

Chemical Property of 2-Hydroxypromazine

Chemical Property:

• Vapor Pressure: 8.14E-10mmHg at 25°C
• Melting Point: >58°C (dec.)
• Boiling Point: 479.4°Cat760mmHg
• Flash Point: 243.8°C
• PSA: 52.01000
• Density: 1.204g/cm³
• LogP: 4.01160
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 300.12963444
• Heavy Atom Count: 21
• Complexity: 339

Purity/Quality:

98%Min ^*data from raw suppliers

2-Hydroxy promazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)O
• Uses: A metabolite of Promazine (P756300).

Technology Process of 2-Hydroxypromazine

There total 4 articles about 2-Hydroxypromazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine (50-53-3) → 10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-ol (3926-64-5)

Guidance literature:

With dicyclohexyl[3,6-dimethoxy-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine; boric acid; palladium diacetate; caesium carbonate; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 14h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03069

Reference yield: 38.0%

chlorpromazine hydrochloride (69-09-0) → 10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-ol (3926-64-5) + promazine (58-40-2)

Guidance literature:

In water; Irradiation;

DOI:10.1039/P29830001313

Reference yield:

10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-ol (3926-64-5) → C17H20N2OS(1+) (3926-64-5)

Guidance literature:

With perchloric acid; Manganase-(III) solution; In water; at 7 ℃; Kinetics; Mechanism; Rate constant; activation parameters;

DOI:10.1039/DT9800000484

upstream raw materials:

2-chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine

2-benzoyloxy-10H-phenothiazine

3-(Dimethylamino)propyl chloride

chlorpromazine hydrochloride

Downstream raw materials:

plutonium (5+)

Refernces

• 1、 Song, Zhi-Qiang,Wang, Dong-Hui. "Palladium-Catalyzed Hydroxylation of Aryl Halides with Boric Acid". supporting information. p. 8470 - 8474. Retrieved 2020/11/18.
• 2、 Huang,Sands. "Effect of ultraviolet irradiation on chlorpromazine. II. Anaerobic condition.". . p. 259 - 264. Retrieved 2007/10/04.