4-{4-[bis(2-hydroxyethyl)amino]phenyl}butanoic acid

Base Information

• Chemical Name: 4-{4-[bis(2-hydroxyethyl)amino]phenyl}butanoic acid
• CAS No.: 34677-78-6
• Molecular Formula: C₁₄H₂₁NO₄
• Molecular Weight: 267.325
• Mol file: 34677-78-6.mol

Synonyms:

Chemical Property of 4-{4-[bis(2-hydroxyethyl)amino]phenyl}butanoic acid

Chemical Property:

• Vapor Pressure: 6.07E-11mmHg at 25°C
• Boiling Point: 503.1°Cat760mmHg
• Flash Point: 258.1°C
• Density: 1.238g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-{4-[bis(2-hydroxyethyl)amino]phenyl}butanoic acid

There total 5 articles about 4-{4-[bis(2-hydroxyethyl)amino]phenyl}butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chlorambucil (305-03-3) → 4-butyric acid (27171-89-7) + 4-phenyl>butyric acid (34677-78-6)

Guidance literature:

With nitric acid; at 37 ℃; Rate constant; Mechanism; Product distribution; pH and buffer concentration on rate of hydrolysisand half-life of title compound;

DOI:10.1002/jps.2600710113

Reference yield:

chlorambucil (305-03-3) → 4-phenyl>butyric acid (34677-78-6)

Guidance literature:

With acetate buffer; nitric acid; In water; at 37 ℃; Rate constant;

Reference yield:

4-butyric acid (27171-89-7) → 4-phenyl>butyric acid (34677-78-6)

Guidance literature:

With water; In methanol; at 25 ℃; Rate constant; μ = 0.1; activation energy; degradation of chlorambucil and its degradation product in aqieous solution, effect of pH and temperature;

DOI:10.1002/jps.2600690928

upstream raw materials:

chlorambucil

4-butyric acid

Thiocyanate

Refernces

• 1、 Haapala,Hakala,Jokipelto,Vilpo,Hovinen. "Reactions of N,N-Bis(2-chloroethyl)-p-aminophenylbutyric acid (chlorambucil) with 2′-deoxyguanosine". . p. 988 - 995. Retrieved 2007/10/03.
• 2、 Chatterji,Yeager,Gallelli. "Kinetics of chlorambucil hydrolysis using high-pressure liquid chromatography". . p. 50 - 54. Retrieved 2007/10/02.