Technology Process of 4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol
There total 5 articles about 4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(2-chlorophenyl)-4-(6,7-dihydro-4H-thieno[3,2-c]pyridine-5-yl)butyric acid ethyl ester;
With
lithium aluminium tetrahydride;
In
diethyl ether;
Inert atmosphere;
Reflux;
With
hydrogenchloride;
In
diethyl ether; water;
With
sodium hydroxide;
In
water;
pH=7;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydrogencarbonate / water
1.2: Inert atmosphere; Reflux
1.3: pH 7
2.1: thionyl chloride / tetrahydrofuran / 20 °C
2.2: pH 7
3.1: ethanol; sodium / 0.08 h / 20 °C / Inert atmosphere
3.2: 2 h / Reflux
4.1: lithium chloride / water; dimethyl sulfoxide / 4 h / 190 °C
5.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere; Reflux
5.3: pH 7
With
lithium aluminium tetrahydride; thionyl chloride; ethanol; sodium; sodium hydrogencarbonate; lithium chloride;
In
tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / tetrahydrofuran / 20 °C
1.2: pH 7
2.1: ethanol; sodium / 0.08 h / 20 °C / Inert atmosphere
2.2: 2 h / Reflux
3.1: lithium chloride / water; dimethyl sulfoxide / 4 h / 190 °C
4.1: lithium aluminium tetrahydride / diethyl ether / Inert atmosphere; Reflux
4.3: pH 7
With
lithium aluminium tetrahydride; thionyl chloride; ethanol; sodium; lithium chloride;
In
tetrahydrofuran; diethyl ether; water; dimethyl sulfoxide;