Cyclohexylamine, N,N-dimethyl-1-phenyl-

Base Information

• Chemical Name: Cyclohexylamine, N,N-dimethyl-1-phenyl-
• CAS No.: 2201-17-4
• Molecular Formula: C14H21 N
• Molecular Weight: 203.327
• Hs Code.: 2921499090
• European Community (EC) Number: 636-643-4
• DSSTox Substance ID: DTXSID10176447
• Nikkaji Number: J294.318B
• Wikidata: Q83046778
• ChEMBL ID: CHEMBL254026
• Mol file: 2201-17-4.mol

Synonyms:2201-17-4;Cyclohexylamine, N,N-dimethyl-1-phenyl-;N,N-dimethyl-1-phenylcyclohexan-1-amine;N,N-Dimethyl-1-phenylcyclohexanamine;Cyclohexylamine, N,N-dimethyl-1-phenyl-,;Cyclohexanamine, N,N-dimethyl-1-phenyl-;CHEMBL254026;SCHEMBL2782210;DTXSID10176447;4-dimethylamino-4-phenylcyclohexane;AKOS024323379;N,N-Dimethyl-1-phenylcyclohexanamine #;N,N-DIMETHYL-1-PHENYLCYCLOHEXYLAMINE

Chemical Property of Cyclohexylamine, N,N-dimethyl-1-phenyl-

Chemical Property:

• Vapor Pressure: 0.00216mmHg at 25°C
• Boiling Point: 289.8°Cat760mmHg
• Flash Point: 117.9°C
• PSA: 3.24000
• Density: 0.96g/cm³
• LogP: 3.40760
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 203.167399674
• Heavy Atom Count: 15
• Complexity: 186

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1(CCCCC1)C2=CC=CC=C2

Technology Process of Cyclohexylamine, N,N-dimethyl-1-phenyl-

There total 5 articles about Cyclohexylamine, N,N-dimethyl-1-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-phenylcyclohexylamine (2201-24-3) → N,N-dimethyl-1-phenylcyclohexyl-1-amine (2201-17-4)

Guidance literature:

With formic acid; Heating;

DOI:10.1021/jm00303a030

Reference yield:

1-(dimethylamino)cyclohexanecarbonitrile (16499-30-2) + phenylmagnesium bromide → N,N-dimethyl-1-phenylcyclohexyl-1-amine (2201-17-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; for 18h; Ambient temperature;

DOI:10.1021/jm00178a014

Reference yield:

1-phenyl-1-cyclohexane (827-52-1,5379-26-0) → N,N-dimethyl-1-phenylcyclohexyl-1-amine (2201-17-4)

Guidance literature:

With tetrachloromethane; N-Bromosuccinimide; Erhitzen des Reaktionsprodukts mit Dimethylamin in Benzol;

upstream raw materials:

1-phenyl-1-cyclohexane

formaldehyd

1-phenylcyclohexylamine

1-(dimethylamino)cyclohexanecarbonitrile

Refernces

• 1、 Lednicer, Daniel,VonVoigtlander, Philip F.,Emmert, D. Edward. "4-Amino-4-arylcyclohexanones and Their Derivatives, a Novel Class of Analgesics. 1. Modification of the Aryl Ring". . p. 424 - 430. Retrieved 2007/10/02.
• 2、 Kalir,Edery,Pelah,Balderman,Porath. "1-Phenycycloalkylamine derivatives. II. Synthesis and pharmacological activity.". . p. 473 - 477. Retrieved 2007/10/05.