2-bromocycloheptanone

Base Information

• Chemical Name: 2-bromocycloheptanone
• CAS No.: 1056246-49-1
• Molecular Formula: C₇H₁₁BrO
• Molecular Weight: 191.068
• Mol file: 1056246-49-1.mol

Synonyms:2-bromocycloheptanone

Chemical Property of 2-bromocycloheptanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-bromocycloheptanone

There total 13 articles about 2-bromocycloheptanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cycloheptanone (502-42-1) → 2-bromocycloheptanone (1056246-49-1)

Guidance literature:

With N-Bromosuccinimide; toluene-4-sulfonic acid; at 20 ℃; for 2.5h;

DOI:10.1016/j.bmc.2011.01.008

Reference yield: 92.0%

N-Bromosuccinimide (128-08-5) + cycloheptanone (502-42-1) → 2-bromocycloheptanone (1056246-49-1)

Guidance literature:

amberlyst-15; In ethyl acetate; at 20 ℃; for 0.333333h;

DOI:10.1016/j.tetlet.2004.11.140

Reference yield: 91.0%

cycloheptanone (502-42-1) → 2,2-dibromo-cycloheptanone + 2-bromocycloheptanone (1056246-49-1)

Guidance literature:

With N-Bromosuccinimide; silica gel; In methanol; for 0.1h; chemoselective reaction; Reflux;

DOI:10.1016/j.cclet.2013.09.014

upstream raw materials:

cycloheptanone

1-dibromomethyl-1-cyclohexanol

(1R,7S)-cycloheptene oxide

1-cycloheptenyl acetate

Downstream raw materials:

2-benzoyloxycycloheptanone

cycloheptanone

2-chlorocycloheptanone

2-hydroxycyloheptanone

Refernces

• 1、 Villieras,J. et al.. "-". . p. 325 - 354. Retrieved 1975.
• 2、 Corey. "-". . p. 2301,2303. Retrieved 1953.
• 3、 Paul, Satya,Gupta, Varinder,Gupta, Rajive,Loupy, André. "Microwave-induced selective synthesis of α-bromo and α,α-dibromoalkanones using dioxane-dibromide and silica gel under solvent-free conditions". . p. 439 - 442. Retrieved 2003.
• 4、 Pravst, Igor,Zupan, Marko,Stavber, Stojan. "Directed regioselectivity of bromination of ketones with NBS: solvent-free conditions versus water". . p. 4707 - 4710. Retrieved 2006.
• 5、 Rahman, Ateeq,Jonnalagadda. "Simple and efficient system for the α-bromination of a β-ketoester by using N-bromosuccinimide in the presence of silicasupported NaHCo3 as the heterogeneous catalyst: An environmentally benevolent approach". . p. 1091 - 1100. Retrieved 2012.
• 6、 -. "Chiral N-heterocyclic carbene catalyst as well as preparation method and application thereof". Paragraph 0009; 0014; 0016-0020. . Retrieved 2021/09/04.
• 7、 Guo, Kun,Kleij, Arjan W.. "Copper-Mediated Dichotomic Borylation of Alkyne Carbonates: Stereoselective Access to (E)-1,2-Diborylated 1,3-Dienes versus Traceless Monoborylation Affording α-Hydroxyallenes". supporting information. p. 4901 - 4906. Retrieved 2021/01/21.