4,5-Dichloroimidazole

Base Information

• Chemical Name: 4,5-Dichloroimidazole
• CAS No.: 15965-30-7
• Molecular Formula: C3H2Cl2N2
• Molecular Weight: 136.968
• Hs Code.: 2933290090
• Mol file: 15965-30-7.mol

Synonyms:Imidazole,4,5-dichloro- (8CI);4,5-Dichloro-1H-imidazole;NSC145392;

Chemical Property of 4,5-Dichloroimidazole

Chemical Property:

• Vapor Pressure: 0.000254mmHg at 25°C
• Melting Point: 183-185 °C(lit.)
• Refractive Index: 1.588
• Boiling Point: 334.1 °C at 760 mmHg
• PKA: 8.99±0.10(Predicted)
• Flash Point: 186.1 °C
• PSA: 28.68000
• Density: 1.613 g/cm³
• LogP: 1.71650
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,5-Dichloroimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn, Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-37/39-36/37/39-22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4,5-Dichloroimidazole has been used in the synthesis of:phosphinite complexes1-hexyl-3-methyl-4,5-dichloroimidazolium iodide, precursor required for the preparation of silver-carbene complex-loaded into L-tyrosine polyphosphate nanoparticles

Technology Process of 4,5-Dichloroimidazole

There total 5 articles about 4,5-Dichloroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1H-imidazole (288-32-4) → 4,5-dichloroimidazole (15965-30-7)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; sulfuric acid; In water; at 0 ℃;

DOI:10.1002/adsc.201200723

Reference yield: 60.0%

4,5-dichloro-imidazole-2-carboxylic acid (64736-53-4) → 4,5-dichloroimidazole (15965-30-7)

Guidance literature:

Heating;

Reference yield: 25.0%

1H-imidazole (288-32-4) → 4-chloro-1H-imidazole (15965-31-8) + 4,5-dichloroimidazole (15965-30-7)

Guidance literature:

With chlorine; In chloroform; Ambient temperature;

DOI:10.1021/jo9814952

upstream raw materials:

4,5-dichloro-imidazole-2-carboxylic acid

1H-imidazole

4,5-dichloro-2-dichloromethylene-2H-imidazole

Downstream raw materials:

(4,5-dichloro-1H-imidazol-2-yl)methanol

4,5-dichloro-1,3-bis(4-methoxybenzyl)imidazolium bromide

4,5-dichloro-2-phenyldiazenyl-1H-imidazole

N-cyclohexyl-2-(2-(4,5-dichloro-1H-imidazol-1-yl)-N-(3,4-difluorophenyl)acetamido)-2-(2,4-difluorophenyl)acetamide

Refernces

• 1、 Hayakawa, Yoshio,Kimoto, Hiroshi,Cohen, Louis A.,Kirk, Kenneth L.. "Syntheses of (trifluoromethyl)imidazoles with additional electronegative substituents, an approach to receptor-activated affinity labels". . p. 9448 - 9454. Retrieved 2007/10/03.
• 2、 -. "4,5-Dichloroimidazole-2-carboxylic acid derivatives". . . Retrieved 2008/06/13.