(R,R-1,2-Diaminocyclohexane)dinitratoplatinum

Base Information

• Chemical Name: (R,R-1,2-Diaminocyclohexane)dinitratoplatinum
• CAS No.: 66900-68-3
• Molecular Formula: C₆H₁₄N₄O₆Pt
• Molecular Weight: 433.28
• Hs Code.: 2843900000
• UNII: H1J83OU9AD
• Mol file: 66900-68-3.mol

Synonyms:H1J83OU9AD;NSC-290132;(R,R-1,2-Diaminocyclohexane)dinitratoplatinum;(1R,2R)-1,2-Cyclohexanediaminedinitratoplatinum;(1R,2R)-1,2-trans-Cyclohexanediamine)dinitratoplatinum(II);(1,2-Cyclohexanediamine-N,N') dinitratoplatinum(II), (sp-4-2-(1R-trans))-;UNII-H1J83OU9AD;(Sp-4-2)-((1R,2R)-1,2-cyclohexanediamine-kappaN1,kappaN2)bis(nitrato-kappaO)platinum;Platinum, ((1R,2R)-1,2-cyclohexanediamine-kappaN,kappaN')bis(nitrato-kappaO)-, (sp-4-2)-;(SP-4-2)-((1R,2R)-1,2-CYCLOHEXANEDIAMINE-.KAPPA.N1,.KAPPA.N2)BIS(NITRATO-.KAPPA.O)PLATINUM;PLATINUM, ((1R,2R)-1,2-CYCLOHEXANEDIAMINE-.KAPPA.N,.KAPPA.N')BIS(NITRATO-.KAPPA.O)-, (SP-4-2)-;PLATINUM, ((1R,2R)-1,2-CYCLOHEXANEDIAMINE-.KAPPA.N1,.KAPPA.N2)BIS(NITRATO-.KAPPA.O)-, (SP-4-2)-;Platinum, ((1R,2R)-1,2-cyclohexanediamine-kappaN1,kappaN2)bis(nitrato-kappaO)-, (sp-4-2)-;PLATINUM, (1,2-CYCLOHEXANEDIAMINE-.KAPPA.N,.KAPPA.N')BIS(NITRATO-.KAPPA.O)-, (SP-4-2-(1R-TRANS))-;Platinum, (1,2-cyclohexanediamine-kappaN,kappaN')bis(nitrato-kappaO)-, (sp-4-2-(1R-trans))-

Chemical Property of (R,R-1,2-Diaminocyclohexane)dinitratoplatinum

Chemical Property:

• Vapor Pressure: 0.46mmHg at 25°C
• Boiling Point: 193.6°Cat760mmHg
• Flash Point: 75°C
• PSA: 134.16000
• Density: g/cm³
• LogP: 1.42490
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 0
• Exact Mass: 433.056129
• Heavy Atom Count: 17
• Complexity: 81.7

Purity/Quality:

90%,98% ^*data from raw suppliers

Oxaliplatin Related Compound B ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(C(C1)N)N.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[Pt+2]
• Isomeric SMILES: C1CC[C@H]([C@@H](C1)N)N.[N+](=O)([O-])[O-].[N+](=O)([O-])[O-].[Pt+2]

Technology Process of (R,R-1,2-Diaminocyclohexane)dinitratoplatinum

There total 3 articles about (R,R-1,2-Diaminocyclohexane)dinitratoplatinum which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) (38780-40-4,52691-24-4,61848-70-2,61848-66-6,61848-62-2) → cis-dinitrato(1,2-diaminocyclohexane)platinum(II) (66900-68-3,66900-69-4,66900-67-2,60732-70-9,125515-54-0)

Guidance literature:

With silver nitrate; In water; solns. of the Pt-complex and AgNO3 in water were mixed, stirred (N2) in the absence of light at 25°C for 2 h; filtn. prepd. in aq. soln.;

DOI:10.1007/BF02546607

Reference yield:

{(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II) (38780-40-4,52691-24-4,61848-70-2,61848-66-6,61848-62-2) + silver nitrate → cis-dinitrato(1,2-diaminocyclohexane)platinum(II) (66900-68-3,66900-69-4,66900-67-2,60732-70-9,125515-54-0)

Guidance literature:

In water; byproducts: AgCl; stirring for 2 h at room temp. in the absence of light and oxygen;; filtered; not isolated;;

DOI:10.1016/S0020-1693(00)81554-6

Reference yield:

(1R,2R)-1,2-diaminocyclohexanedichloroplatinum(II) (61848-66-6) + silver nitrate → Pt(R,R-DACH)(NO3)2 (66900-68-3)

Guidance literature:

In water; an aq. soln. of AgNO3 was added with stirring to a slurry of Pt(R,R-DACH)Cl2 in H2O; after heating at 50°C for 0.5h, the slurry was cooled and stirring was continued 12h in the dark;; soln. of (Pt(R,R-DACH)(H2O)2)(2+)*2NO3(1-) was lyophilized under high vacuum; elem.anal.;;

upstream raw materials:

{(1R,2R)-cyclohexane-1,2-diamine}dichloridoplatinum(II)

(1R,2R)-1,2-diaminocyclohexanedichloroplatinum(II)

Refernces

• 1、 Hoeschele, James D.,Farrell,Turner,Rithner, Christopher D.. "Synthesis and characterization of diastereomeric (substituted iminodiacetato) (1,2- diaminocyclohexane)platinum(II) complexes". . p. 4106 - 4113. Retrieved 2008/10/08.