5-aminomethyl-2-methylpyrimidin-4-ylamine dihydrochloride

Base Information

• Chemical Name: 5-aminomethyl-2-methylpyrimidin-4-ylamine dihydrochloride
• CAS No.: 874-43-1
• Molecular Formula: C₆H₁₀N₄*2ClH
• Molecular Weight: 211.094
• Hs Code.: 2933599090
• Mol file: 874-43-1.mol

Synonyms:5-Pyrimidinemethanamine,4-amino-2-methyl-, dihydrochloride (9CI);Pyrimidine, 4-amino-5-(aminomethyl)-2-methyl-,dihydrochloride (8CI);5-(aminomethyl)-2-methylpyrimidin-4-amine dihydrochloride;

Chemical Property of 5-aminomethyl-2-methylpyrimidin-4-ylamine dihydrochloride

Chemical Property:

• Vapor Pressure: 0.00104mmHg at 25°C
• Melting Point: 270-272°C
• Boiling Point: 301.6 °C at 760 mmHg
• Flash Point: 161.5 °C
• PSA: 77.82000
• LogP: 2.71140
• Storage Temp.: -20°C Freezer

Purity/Quality:

99%, ^*data from raw suppliers

4-Amino-5-aminomethyl-2-methylpyrimidineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Substrate for TenA enzyme in the thiamin salvage pathway

Technology Process of 5-aminomethyl-2-methylpyrimidin-4-ylamine dihydrochloride

There total 3 articles about 5-aminomethyl-2-methylpyrimidin-4-ylamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(2-hydroxy-ethyl)-4-methyl-3H-thiazol-2-one (32795-64-5) + N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-hydroxy-1-methyl-2-thiocyanato-but-1-en-t-yl)-formamide (2421-50-3) → 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-3a-methyl-tetrahydro-furo[2,3-d]thiazol-2-ylideneamine (120745-11-1) + 5-(aminomethyl)-2-methylpyrimidin-4-amine dihydrochloride (874-43-1,1195-07-9,25449-06-3)

Guidance literature:

With hydrogenchloride;

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + water (7732-18-5) + N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-hydroxy-1-methyl-2-thiocyanato-but-1-en-t-yl)-formamide (2421-50-3) → 5-(2-hydroxy-ethyl)-4-methyl-3H-thiazol-2-one (32795-64-5) + 5-(aminomethyl)-2-methylpyrimidin-4-amine dihydrochloride (874-43-1,1195-07-9,25449-06-3)

Guidance literature:

at 100 ℃;

Reference yield:

→ 5-(aminomethyl)-2-methylpyrimidin-4-amine dihydrochloride (874-43-1,1195-07-9,25449-06-3)

Guidance literature:

upstream raw materials:

5-(2-hydroxy-ethyl)-4-methyl-3H-thiazol-2-one

N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(4-hydroxy-1-methyl-2-thiocyanato-but-1-en-t-yl)-formamide

hydrogenchloride

water

Downstream raw materials:

7-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

(R/S)-N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)acetamide

methyl 2-(4-(6-((4-amino-2-methylpyrimidin-5-yl)methylamino)pyrimidin-4-yloxy)phenyl)acetate

3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-phenyl-3H-thiazole-2-thione

Refernces