Acetamide, N-[4-[(2-hydroxyethyl)sulfonyl]phenyl]-

Base Information

• Chemical Name: Acetamide, N-[4-[(2-hydroxyethyl)sulfonyl]phenyl]-
• CAS No.: 27375-52-6
• Molecular Formula: C10H13 N O4 S
• Molecular Weight: 243.284
• European Community (EC) Number: 248-433-6
• DSSTox Substance ID: DTXSID4067305
• Nikkaji Number: J54.159A
• Wikidata: Q72484252
• Mol file: 27375-52-6.mol

Synonyms:27375-52-6;N-[4-(2-hydroxyethylsulfonyl)phenyl]acetamide;N-(4-((2-HYDROXYETHYL)SULFONYL)PHENYL)ACETAMIDE;N-{4-[(2-hydroxyethyl)sulfonyl]phenyl}acetamide;Acetamide, N-[4-[(2-hydroxyethyl)sulfonyl]phenyl]-;p-Acetaminofenyl-2-hydroxyethylsulfon [Czech];EINECS 248-433-6;4'-(2-Hydroxyethylsulfonyl)acetanilide;BRN 2742434;N-[4-(2-hydroxyethanesulfonyl)phenyl]acetamide;p-Acetaminofenyl-beta-hydroxyethylsulfon [Czech];p-Acetaminofenyl-2-hydroxyethylsulfon;Acetamide, N-(4-((2-hydroxyethyl)sulfonyl)phenyl)-;p-Acetaminofenyl-beta-hydroxyethylsulfon;EC 248-433-6;N-(4-((2-Hydroxyethyl)sulphonyl)phenyl)acetamide;3-13-00-01276 (Beilstein Handbook Reference);ACETANILIDE, 4'-(2-HYDROXYETHYLSULFONYL)-;N-(4-(2-hydroxyethylsulfonyl)phenyl)acetamide;N-[4-[(2-hydroxyethyl)sulphonyl]phenyl]acetamide;Cambridge id 5255854;TimTec1_001025;Oprea1_192045;SCHEMBL5711952;DTXSID4067305;HMS1536O13;BBL001180;MFCD00454261;STK368410;AKOS005444230;2-(4-Acetylaminophenylsulfonyl)ethanol;NCGC00174873-01;VS-00837;4-(beta-Hydroxyethylsulfonyl)-N-Aacetanilide;N-[4-(2-hydroxyethylsulfonyl)phenyl]ethanamide;A819039;N-[4-[(2-Hydroxyethyl)sulphonyl]phenyl] acetamide;W-107115;BRD-K64632684-001-01-9

Chemical Property of Acetamide, N-[4-[(2-hydroxyethyl)sulfonyl]phenyl]-

Chemical Property:

• Vapor Pressure: 4.52E-13mmHg at 25°C
• Refractive Index: 1.6800 (estimate)
• Boiling Point: 553.2°Cat760mmHg
• PKA: 0[at 20 ℃]
• Flash Point: 288.3°C
• PSA: 91.85000
• Density: 1.364g/cm³
• LogP: 1.56480
• Solubility.: 2g/L in organic solvents at 20 ℃
• Water Solubility.: 2g/L at 30℃
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 243.05652907
• Heavy Atom Count: 16
• Complexity: 325

Purity/Quality:

99.9% ^*data from raw suppliers

4-(-BETA-HYDROXYETHYL-SULFONYL)-N-ACETANILIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)S(=O)(=O)CCO

Technology Process of Acetamide, N-[4-[(2-hydroxyethyl)sulfonyl]phenyl]-

There total 5 articles about Acetamide, N-[4-[(2-hydroxyethyl)sulfonyl]phenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H13NO2S → acetic acid-[4-(2-hydroxy-ethanesulfonyl)-anilide] (27375-52-6)

Guidance literature:

With sodium tungstate; dihydrogen peroxide; sodium carbonate; at 50 ℃; for 2h; pH=6; Reagent/catalyst; pH-value;

Reference yield:

sodium 4-acetamidobenzenesulfinate (15898-43-8) + 2-chloro-ethanol (107-07-3) → acetic acid-[4-(2-hydroxy-ethanesulfonyl)-anilide] (27375-52-6)

Guidance literature:

ohne Loesungsmittel;

Reference yield:

4-chlorobenzonitrile (100-00-5) → acetic acid-[4-(2-hydroxy-ethanesulfonyl)-anilide] (27375-52-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium sulfide; water / 10 h / 101 - 105 °C

2.1: 1 h / 20 °C

2.2: 1 h

3.1: 80 - 140 °C

4.1: sodium tungstate; dihydrogen peroxide; sodium carbonate / 2 h / 50 °C / pH 6

With sodium sulfide; sodium tungstate; water; dihydrogen peroxide; sodium carbonate;

upstream raw materials:

sodium 4-acetamidobenzenesulfinate

2-chloro-ethanol

4-chlorobenzonitrile

sodium 4-aminothiophenolate

Downstream raw materials:

acetic acid-[4-(2-phenylsulfanyl-ethanesulfonyl)-anilide]

P-aminobenzene-β-hydroxyethyl sulfone sulfate

2-(p-aminophenylsulfonyl)ethyl hydrogen sulfate

4-(2-methoxyethylsulfonyl)benzenamine

Refernces