C₂₆H₂₈N₂O₅

Base Information

• Chemical Name: C₂₆H₂₈N₂O₅
• CAS No.: 473578-35-7
• Molecular Formula: C₂₆H₂₈N₂O₅
• Molecular Weight: 448.519
• Mol file: 473578-35-7.mol

Synonyms:C₂₆H₂₈N₂O₅

Chemical Property of C₂₆H₂₈N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₈N₂O₅

There total 5 articles about C₂₆H₂₈N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-bromoethyl)phenol (14140-15-9) + C18H20N2O4 (473578-34-6) → C26H28N2O5 (473578-35-7)

Guidance literature:

With polymer-supprted carbonate base; In acetonitrile; at 140 ℃; for 0.5h; MW irradiation;

DOI:10.1002/1521-3773(20020617)41:12<2194::AID-ANIE2194>3.0.CO;2-4

Reference yield:

p-hydroxyphenethyl alcohol (501-94-0) → C26H28N2O5 (473578-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / carbon tetrabromide; diphenylphosphino-polystyrene / CH₂Cl₂ / 3.5 h / 40 °C

2: IRA 900 polymer-supported carbonate / acetonitrile / 0.5 h / 140 °C / microwave irradiation

With diphenylphosphino-polystyrene; carbon tetrabromide; IRA 900 polymer-supported carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(02)00628-2

Reference yield:

C19H17F3N2O5 (473578-32-4) → C26H28N2O5 (473578-35-7)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfonic acid resin (MP-TsOH) / CH₂Cl₂; methanol; hexane / 0 °C

2: Ambersep 900 (OH-form) / methanol / 0.33 h / 100 °C / microwave irradiation

3: IRA 900 polymer-supported carbonate / acetonitrile / 0.5 h / 140 °C / microwave irradiation

With Ambersep 900 (OH-form); IRA 900 polymer-supported carbonate; sulfonic acid resin (MP-TsOH); In methanol; hexane; dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(02)00628-2

upstream raw materials:

4-(2-bromoethyl)phenol

C₁₈H₂₀N₂O₄

p-hydroxyphenethyl alcohol

C₁₉H₁₅F₃N₂O₅

Refernces

• 1、 Baxendale, Ian R,Ley, Steven V,Nessi, Marcella,Piutti, Claudia. "Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents". . p. 6285 - 6304. Retrieved 2007/10/03.