Pteroyltriglutamic

Base Information

• Chemical Name: Pteroyltriglutamic
• CAS No.: 89-38-3
• Molecular Formula: C29H33 N9 O12
• Molecular Weight: 699.634
• Mol file: 89-38-3.mol

Synonyms:Glutamicacid, N-[N-(N-pteroyl-L-g-glutamyl)-L-g-glutamyl]-, L- (6CI,7CI,8CI); L-Glutamic acid,N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl-L-g-glutamyl- (9CI); L-Glutamicacid, N-[N-[N-[4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-g-glutamyl]-L-g-glutamyl]-; Fermentation L.casei factor; Folic acid diglutamate; PTGA; Pteropterin; Pteroyl-L-glutamyl-g-L-glutamyl-g-L-glutamic acid; Pteroyl-g-triglutamic acid; Pteroyltri-g-L-glutamic acid;Pteroyltriglutamic acid

Chemical Property of Pteroyltriglutamic

Chemical Property:

• PKA: 3.39±0.10(Predicted)
• PSA: 49.81000
• Density: 1.68±0.1 g/cm3(Predicted)
• LogP: 4.96088

Purity/Quality:

99% ^*data from raw suppliers

Pteroyltri-γ-L-glutamicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Pteroyltri-γ-L-glutamic acid is a folate derivative found in various foods such as yeast, spinach, beef liver, beef fillet and peas.

Technology Process of Pteroyltriglutamic

There total 6 articles about Pteroyltriglutamic which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-pteroyl-L-γ-glutamyl=>L-γ-glutamyl=>L-glutamic acid (89-38-3)

Guidance literature:

With hydrogenchloride; zinc; und anschliessenden Umsetzung mit 2,5,6-Triamino-3H-pyrimidin-4-on-sulfat und 2,3-Dibrom-propionaldehyd;

DOI:10.1021/ja01175a010

Reference yield:

L-glutamic acid α-tert-butyl ester (45120-30-7) → folyl-tri-γ-L-glutamic acid (89-38-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 85 percent / 10percent Na₂CO₃ / dioxane / 20 h / 24 °C

2: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

3: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

4: 0.1N HCl / tetrahydrofuran / 18 h / 25 °C

5: 0.1 N NaOH

With piperidine; 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; KH polyamide resin; sodium carbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

DOI:10.1021/jm00164a038

Reference yield:

Fmoc-Glu-OtBu (84793-07-7) → folyl-tri-γ-L-glutamic acid (89-38-3)

Guidance literature:

Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide / CH₂Cl₂ / 0.25 h

2: KH polyamide resin, 4-(dimethylamino)pyridine, N-methylmorpholine, piperidine, 1percent TFA

3: 0.1N HCl / tetrahydrofuran / 18 h / 25 °C

4: 0.1 N NaOH

With piperidine; 4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; KH polyamide resin; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00164a038

upstream raw materials:

(S)-2-[(S)-4-((S)-4-{4-[(2-Amino-4-hydroxy-pteridin-6-ylmethyl)-(2,2,2-trifluoro-acetyl)-amino]-benzoylamino}-4-carboxy-butyrylamino)-4-carboxy-butyrylamino]-pentanedioic acid

L-glutamic acid α-tert-butyl ester

Fmoc-Glu-OtBu

α-tert-butyl N-<(9-fluorenylmethoxy)oxy>carbonyl-L-glutamic anhydride

Refernces