8-chloro-6-phenylphenanthridine

Base Information

• Chemical Name: 8-chloro-6-phenylphenanthridine
• CAS No.: 109394-17-4
• Molecular Formula: C₁₉H₁₂ClN
• Molecular Weight: 289.764
• Mol file: 109394-17-4.mol

Synonyms:8-chloro-6-phenylphenanthridine

Chemical Property of 8-chloro-6-phenylphenanthridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-chloro-6-phenylphenanthridine

There total 19 articles about 8-chloro-6-phenylphenanthridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4'‐chloro‐2‐isocyano‐1,1'‐biphenyl (1453098-10-6) + aniline (62-53-3) → 8-chloro-6-phenylphenanthridine (109394-17-4)

Guidance literature:

With tert.-butylnitrite; sodium acetate; N,N`-dimethylethylenediamine; dibenzoyl peroxide; at 20 - 70 ℃; for 3.08333h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol500923t

Reference yield: 83.0%

2'-benzyl-4'-chloro-[1,1'-biphenyl]-2-amine → 8-chloro-6-phenylphenanthridine (109394-17-4)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; iodine; caesium carbonate; at 80 ℃; for 2h;

DOI:10.1039/d0ob00433b

Reference yield: 82.0%

4'‐chloro‐2‐isocyano‐1,1'‐biphenyl (1453098-10-6) + dibenzoyl peroxide (94-36-0) → 8-chloro-6-phenylphenanthridine (109394-17-4)

Guidance literature:

at 100 ℃; for 10h; Inert atmosphere;

DOI:10.1039/c4cc10015h

upstream raw materials:

2-chloro-11-phenyl-dibenzo[b,f][1,4]thiazepine

N-(4'-chloro-biphenyl-2-yl)-benzamide

benzoic acid-[2-(4-chloro-phenylsulfanyl)-anilide]

4'‐chloro‐2‐isocyano‐1,1'‐biphenyl

Refernces

• 1、 Chang, Junbiao,Fang, Benyao,Hou, Jiao,Tian, Jinyue,Yu, Wenquan. "Synthesis of phenanthridines by I2-mediated sp3C-H amination". . p. 3312 - 3323. Retrieved 2020/05/14.
• 2、 Ge, Jun,Wang, Xiaojian,Liu, Tianqi,Shi, Zeyu,Xiao, Qiong,Yin, Dali. "Assembly of substituted phenanthridines via a cascade palladium-catalyzed coupling reaction, deprotection and intramolecular cyclization". . p. 19571 - 19575. Retrieved 2016/03/01.