Technology Process of 4-toluamidooxindole
There total 4 articles about 4-toluamidooxindole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
1,4-dioxane; pyridine;
for 24h;
Ambient temperature;
DOI:10.1021/jo00163a006
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 70 percent / 70percent perchloric acid / acetic acid / 1 h / Heating
2: 94 percent / 10percent palladium on carbon, H2 / methanol / 2.) reflux, 72 h
3: 88 percent / pyridine; dioxane / 24 h / Ambient temperature
With
palladium on activated charcoal; perchloric acid; hydrogen;
In
1,4-dioxane; pyridine; methanol; acetic acid;
DOI:10.1021/jo00163a006
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) potassium tert-butoxide / 1.)DMF, 2.) 20 to 90 deg C, 2 h, 25 deg C, 16 h, to 10 deg C
2: 70 percent / 70percent perchloric acid / acetic acid / 1 h / Heating
3: 94 percent / 10percent palladium on carbon, H2 / methanol / 2.) reflux, 72 h
4: 88 percent / pyridine; dioxane / 24 h / Ambient temperature
With
palladium on activated charcoal; perchloric acid; potassium tert-butylate; hydrogen;
In
1,4-dioxane; pyridine; methanol; acetic acid;
DOI:10.1021/jo00163a006
