5α-Ergosta-7,22-dien-3β-ol acetate

Base Information

• Chemical Name: 5α-Ergosta-7,22-dien-3β-ol acetate
• CAS No.: 1449-60-1
• Molecular Formula: C₃₀H₄₈O₂
• Molecular Weight: 440.71
• Mol file: 1449-60-1.mol

Synonyms:5-dihydroergosteryl acetate

Chemical Property of 5α-Ergosta-7,22-dien-3β-ol acetate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5α-Ergosta-7,22-dien-3β-ol acetate

There total 50 articles about 5α-Ergosta-7,22-dien-3β-ol acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(22E)-ergosta-7,22-dien-3β-ol (2465-11-4) + acetyl chloride (75-36-5) → 5-dihydroergosteryl acetate (1449-60-1)

Guidance literature:

With pyridine; at 20 ℃; for 2h;

DOI:10.1002/anie.201706086

Reference yield: 88.0%

(22E)-ergosta-7,22-dien-3β-ol (2465-11-4) + acetic anhydride (108-24-7) → 5-dihydroergosteryl acetate (1449-60-1)

Guidance literature:

With pyridine; at 20 ℃; for 16h;

DOI:10.1016/j.steroids.2022.108965

Reference yield: 27.0%

3β-acetoxy-5α,8α-(4-phenyl-1,2,4-triazolidine-3,5-dione-1,2-diyl)ergosta-6,22-diene (28421-56-9) → brassicasterol acetate (2458-53-9) + 5-dihydroergosteryl acetate (1449-60-1)

Guidance literature:

With lithium; ethylamine; for 0.5h; Heating;

DOI:10.1039/c39820001169

upstream raw materials:

(10S)-3c-Hydroxy-10r.13c-dimethyl-17c-((1R:4R)-1.4.5-trimethyl-hexen-(2t)-yl)-(5ξH.9cH.14tH)-Δ⁷-tetradecahydro-1H-cyclopenta[a]phenanthren

acetic anhydride

(10R)-3c-Hydroxy-10r.13c-dimethyl-17c-((1R:4R)-1.4.5-trimethyl-hexen-(2t)-yl)-(9cH.14tH)-Δ^5.7-dodecahydro-1H-cyclopenta[a]phenanthren

5β-lumistadien-(7.22t)-ol-(3α)

Downstream raw materials:

(3S,5S,8R,9S,10S,13R,17R)-17-((2R,5R,E)-5,6-dimethylhept-3-en-2-yl)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

3β-acetoxy-5α-ergosta-8(14),22t-diene

(3S,5S,7S,8S,9R,10S,13R,14R,17R)-10,13-Dimethyl-17-((E)-(1R,4R)-1,4,5-trimethyl-hex-2-enyl)-hexadecahydro-cyclopropa[7,8]cyclopenta[a]phenanthren-3-ol

(3β,5α)-ergost-8(14)-en-3-ol

Refernces

• 1、 Lin, Chun-Nan,Tome, Whey-Pin,Won, Shen-Jeu. "A LANOSTANOID OF FORMOSAN GANODERMA LUCIDUM". . p. 673 - 675. Retrieved 1990.
• 2、 Sato, Shuntaro,Fukuda, Yuki,Ogura, Yusuke,Kwon, Eunsang,Kuwahara, Shigefumi. "Synthesis of the Epimeric Secosteroids Strophasterols A and B". supporting information. p. 10911 - 10914. Retrieved 2017/08/30.