Butropipazone

Base Information

• Chemical Name: Butropipazone
• CAS No.: 2354-61-2
• Molecular Formula: C20H23 F N2 O
• Molecular Weight: 326.45
• Hs Code.: 2933599090
• NSC Number: 170975
• UNII: 47UB2NB3UD
• DSSTox Substance ID: DTXSID50178122
• Nikkaji Number: J42.938D
• Wikidata: Q83048458
• ChEMBL ID: CHEMBL2362425
• Mol file: 2354-61-2.mol

Synonyms:Butropipazone;Galvanisone;Butropipazon;Butyropipazone;2354-61-2;1-(4-fluorophenyl)-4-(4-phenylpiperazin-1-yl)butan-1-one;1-Butanone, 1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)-;R 1892;NSC 170975;BUTYROPHENONE, 4'-FLUORO-4-(4-PHENYL-1-PIPERAZINYL)-;4'-Fluoro-4-(1-(4-phenyl)piperazino)butyrophenone;gamma-(4-Phenylpiperazino)-4-fluorobutyrophenone;BRN 0895232;47UB2NB3UD;MLS003106750;NSC-170975;.gamma.-(4-Phenylpiperazino)-4-fluorobutyrophenone;5-23-02-00209 (Beilstein Handbook Reference);4'-Fluoro-4-[1-(4-phenyl)piperazino]butyrophenone;UNII-47UB2NB3UD;Oprea1_538932;C20H23FN2O;SCHEMBL6234537;CHEMBL2362425;DTXSID50178122;QPHRVUMZLUQZGU-UHFFFAOYSA-N;WLN: T6NTJ A1OR DF& DR;C20-H23-F-N2-O;NSC170975;STK544074;AKOS005473486;LS-48423;SMR001821639;Z137558384;1-(4-Fluorophenyl)-4-(4-phenyl-1-piperazinyl)-1-butanone;1-(4-Fluorophenyl)-4-(4-phenyl-1-piperazinyl)-1-butanone #;1-Butanone, 1-(4-fluorophenyl)-4-(4-phenyl-1-piperazinyl)- (9CI)

Chemical Property of Butropipazone

Chemical Property:

• Vapor Pressure: 2.03E-09mmHg at 25°C
• Boiling Point: 481.2°Cat760mmHg
• Flash Point: 244.8°C
• PSA: 23.55000
• Density: 1.137g/cm³
• LogP: 3.61370
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 326.17944152
• Heavy Atom Count: 24
• Complexity: 381

Purity/Quality:

99% ^*data from raw suppliers

Butropipazon ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCCC(=O)C2=CC=C(C=C2)F)C3=CC=CC=C3
• Uses: Butropipazon is derived from 1-Phenylpiperazine (P336040), which was tested for its activity as a topical glaucoma agent.

Technology Process of Butropipazone

There total 2 articles about Butropipazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

γ-(4-phenylpiperazino)-2-amino-4-fluorobutyrophenone + hypophosphorous acid (6303-21-5) → butropipazone (2354-61-2)

Guidance literature:

With hydrogenchloride; sodium hydroxide; sodium nitrite; In water;

Reference yield:

→ butropipazone (2354-61-2)

Guidance literature:

1-Phenyl-piperazin, entspr. Chlorid;

upstream raw materials:

hypophosphorous acid

Refernces