4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester

Base Information

• Chemical Name: 4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester
• CAS No.: 797751-17-8
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Mol file: 797751-17-8.mol

Synonyms:4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester

Chemical Property of 4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester

There total 2 articles about 4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-phenylmethyl-4-piperidone (3612-20-2) + propargyl chloroformate (35718-08-2) → 4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester (797751-17-8)

Guidance literature:

1-phenylmethyl-4-piperidone; propargyl chloroformate; In chloroform; at -23 ℃;

In chloroform; at 20 ℃; for 0.2h; Further stages.;

DOI:10.1016/j.tetlet.2004.09.018

Reference yield: 65.0%

1-Isopropyl-4-piperidone (5355-68-0) + propargyl chloroformate (35718-08-2) → 4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester (797751-17-8)

Guidance literature:

1-Isopropyl-4-piperidone; propargyl chloroformate; In chloroform; at -23 ℃;

In chloroform; for 0.75h; Further stages.; Heating;

DOI:10.1016/j.tetlet.2004.09.018

Reference yield: 97.0%

4-oxo-piperidine-1-carboxylic acid prop-2-ynyl ester (797751-17-8) → piperidin-4-one (41661-47-6)

Guidance literature:

With benzyltriethylammonium tetrathiomolybdate; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.09.018

upstream raw materials:

1-Isopropyl-4-piperidone

propargyl chloroformate

1-phenylmethyl-4-piperidone

Downstream raw materials:

piperidin-4-one

Refernces