Technology Process of methyl (13S,15S,16R,18S)-13-[(1S,9S,10R,11S,12S,19S)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate
There total 5 articles about methyl (13S,15S,16R,18S)-13-[(1S,9S,10R,11S,12S,19S)-11-acetyloxy-12-ethyl-10-hydroxy-5-methoxy-10-methoxycarbonyl-8-methyl-8,16-diazapentacyclo[10.6.1.01,9.02,7.016,19]nonadeca-2,4,6,13-tetraen-4-yl]-18-ethyl-17-oxa-1,11-diazapentacyclo[13.4.1.04,12.05,10.016,18]icosa-4(12),5,7,9-tetraene-13-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate; flavin adenine dinucleotide; manganese(ll) chloride;
Product distribution;
Multistep reaction; biotransformation of 3',4'-anhydrovinblastine by C. roseus cultures (cell line AC3) in 1-B5 medium;
- Guidance literature:
-
With
cell-free extracts from Catharanthus roseus;
Product distribution;
Mechanism;
Ambient temperature;
biosynthesis of the products were studied; experiment was performed with 3',4'-anhydrovinblastine and the incorporation of the radiolabel into the products were investigated;
DOI:10.1002/hlca.19820650716
- Guidance literature:
-
With
Flavin mononucleotide; manganese(ll) chloride;
In
water;
at 25 ℃;
pH=7;
Tris-HCl buffer;
near-ultraviolet light irradiation;
DOI:10.1271/bbb.90545