(+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE

Base Information

• Chemical Name: (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE
• CAS No.: 5654-83-1
• Molecular Formula: C7H14N2
• Molecular Weight: 126.202
• Hs Code.: 2933990090
• Mol file: 5654-83-1.mol

Synonyms:1,2,3,4,6,7,8,8a-Octahydropyrrolo[1,2-a]pyrazine;1,2-Trimethylenepiperazine;1,4-Diazabicyclo[4.3.0]nonane;Octahydropyrrolo[1,2-a]pyrazine;

Chemical Property of (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE

Chemical Property:

• Vapor Pressure: 0.338mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 199.639 °C at 760 mmHg
• PKA: 9.98±0.20(Predicted)
• Flash Point: 88.833 °C
• PSA: 15.27000
• Density: 1.03 g/cm³
• LogP: 0.32070
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

Octahydropyrrolo[1,2-A]pyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE

There total 10 articles about (+/-)-1,4-DIAZABICYCLO[4.4.0]DECANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3,4-dihydropyrrolo[1,2-a]-pyrazine (71257-37-9) → octahydropyrrolo[1,2-a]pyrazine (5654-83-1)

Guidance literature:

With hydrogen; nickel; In isopropyl alcohol; at 150 - 160 ℃; for 2h; under 114000 Torr;

DOI:10.1007/BF00780552

Reference yield: 61.0%

Hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione (19179-12-5) → octahydropyrrolo[1,2-a]pyrazine (5654-83-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

Reference yield: 47.5%

3,4-Dihydro-pyrrolo[1,2-a]pyrazine; hydrochloride → octahydropyrrolo[1,2-a]pyrazine (5654-83-1)

Guidance literature:

With hydrogen; platinum(IV) oxide; In water; for 50h;

DOI:10.1007/BF00780552

upstream raw materials:

2,3-dioxo-1,4-diazabicyclo<4.3.0>nonane

Hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

3,4-dihydropyrrolo[1,2-a]-pyrazine

1,4-diazabicyclo<4.3.0>nonan-5-one

Downstream raw materials:

4-(β-phen yl-β-hydroxyethyl)-1,4-diazabicyclo<4.3.0>nonane

1-(Hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-3-phenoxy-propan-2-ol

4-(2-oxo-4-n-butyl)-1,4-diazabicyclo<4.3.0>nonane

C₁₉H₂₂ClN₃O₆S

Refernces

• 1、 Macías, Alberto,Alonso, Eduardo,Del Pozo, Carlos,González, Javier. "Unusual rearrangement of spiro β-lactams to 1,4-diazabicyclo[4,4,0] decanes and 1,4-diazabicyclo[4,3,0]nonanes. Synthesis of conformationally restricted σ-receptor ligands". . p. 4657 - 4660. Retrieved 2007/10/03.
• 2、 Nazarova, L. S.,Rozonov, Yu. B.,Likhosherstov, A. M.,Morozova, T. V.,Skoldinov, A. P.,et al.. "AZACYCLOALKANES. XXVII. SYNTHESIS AND ANTIANGINAL ACTIVITY OF NONACHLAZINE STEREOISOMERS". . p. 811 - 815. Retrieved 2007/10/02.