Isoxazole-curcumin

Base Information

• Chemical Name: Isoxazole-curcumin
• CAS No.: 114380-40-4
• Molecular Formula: C₂₁H₁₉NO₅
• Molecular Weight: 365.386
• Mol file: 114380-40-4.mol

Synonyms:Isoxazole-curcumin

Chemical Property of Isoxazole-curcumin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoxazole-curcumin

There total 9 articles about Isoxazole-curcumin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1E,4Z,6E)-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one (814919-70-5) → Isoxazole-curcumin (114380-40-4)

Guidance literature:

With hydroxylamine hydrochloride; acetic acid; at 70 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.3390/molecules22040633

Reference yield: 89.0%

curcumin (458-37-7) → Isoxazole-curcumin (114380-40-4)

Guidance literature:

With hydroxylamine hydrochloride; acetic acid; In ethanol; for 40h; Reflux;

DOI:10.1016/j.bmc.2008.10.057

Reference yield: 83.0%

curcumin (458-37-7) → 3,5-bis[β-(4-hydroxy-3-methoxyphenyl)ethenyl]isoxazole (114380-40-4)

Guidance literature:

With hydroxylamine hydrochloride; acetic acid; for 0.0333333h; Microwave irradiation;

DOI:10.1016/j.bmc.2012.08.029

upstream raw materials:

curcumin

vanillin

curcumin

curcumin

Downstream raw materials:

(E,E)-3,5-bis(3,4-dimethoxystyryl)isoxazole

C₂₂H₂₁NO₅

C₂₂H₂₁NO₅

C₂₆H₂₇NO₅

Refernces

• 1、 Selvam,Jachak, Sanjay M.,Thilagavathi, Ramasamy,Chakraborti, Asit. K.. "Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents". . p. 1793 - 1797. Retrieved 2005.
• 2、 Sharma, Manisha,Rani, Swati,Mozumdar, Subho. "Perturbations in the photophysical properties of isoxazole derivative of curcumin up on interaction with different anionic, cationic and non-ionic surfactants". . . Retrieved 2021.
• 3、 Hari, Gangadhar,Kumar, N. V. Anil,Pai, K. S. R.,Rodrigues, Fiona C.,Thakur, Goutam. "The inhibitory potency of isoxazole-curcumin analogue for the management of breast cancer: A comparative in vitro and molecular modeling investigation". . p. 5995 - 6008. Retrieved 2021/07/26.