2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester

Base Information

• Chemical Name: 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester
• CAS No.: 102609-81-4
• Molecular Formula: C₂₈H₂₆N₂O₈
• Molecular Weight: 518.523
• Mol file: 102609-81-4.mol

Synonyms:2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester

Chemical Property of 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester

There total 2 articles about 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-amino-succinic acid dibenzyl ester (4079-61-2) + Chlorameisensaeure-N-5-hydroxy-norbornen-2,3-dicarboximidester (99502-89-3) → N-hydroxy-5-norbomene-2,3-dicarboxylic acid imide (1195164-50-1,397299-61-5) + 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester (102609-81-4)

Guidance literature:

With triethylamine; In dichloromethane; at -5 ℃; for 0.5h;

Reference yield:

2-amino-succinic acid dibenzyl ester (4079-61-2) + Chlorameisensaeure-N-5-hydroxy-norbornen-2,3-dicarboximidester (99502-89-3) → 2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester (102609-81-4)

Guidance literature:

With triethylamine; In dichloromethane;

Reference yield:

2-((1S,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yloxycarbonylamino)-succinic acid dibenzyl ester (102609-81-4) → 3-Benzylsulfanyl-2-[3-(2-benzylsulfanyl-1-ethoxycarbonyl-ethyl)-ureido]-propionic acid ethyl ester (102609-51-8)

Guidance literature:

With water; In 1,4-dioxane; at 80 - 90 ℃; for 0.333333h;

upstream raw materials:

2-amino-succinic acid dibenzyl ester

Chlorameisensaeure-N-5-hydroxy-norbornen-2,3-dicarboximidester

Downstream raw materials:

3-Benzylsulfanyl-2-[3-(2-benzylsulfanyl-1-ethoxycarbonyl-ethyl)-ureido]-propionic acid ethyl ester

Refernces

• 1、 Henklein,Boettcher,Heder,Siems,Niedrich. "Synthesis of carbonyl-bisamino acid derivatives as potential ACE inhibitors". . p. 56 - 57. Retrieved 2007/10/02.