2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone

Base Information

• Chemical Name: 2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone
• CAS No.: 65932-49-2
• Molecular Formula: C₃₁H₃₁NO₅
• Molecular Weight: 497.591
• Mol file: 65932-49-2.mol

Synonyms:2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone

Chemical Property of 2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone

There total 1 articles about 2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

estradiol (50-28-2) + 2-chloro-5-nitrobenzophenone (34052-37-4) → 2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone (65932-49-2)

Guidance literature:

With potassium hydroxide; In ethanol; for 3h; Product distribution / selectivity; Heating / reflux;

Reference yield:

2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone (65932-49-2) → 3-benzoyloxy-2-methoxyestra-1,3,5(10)-trien-17β-ol (84509-93-3)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / beim Behandeln des Reaktionsprodukts mit wss. H₂O₂ in Essigsaeure und H₂SO₄

3: ethanolic KOH

With pyridine; potassium hydroxide;

DOI:10.1021/ja01538a050

Reference yield:

2-(17β-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone (65932-49-2) → 2-(17β-hydroxy-2-methoxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone (65932-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / beim Behandeln des Reaktionsprodukts mit wss. H₂O₂ in Essigsaeure und H₂SO₄

3: ethanolic H₂SO₄

With pyridine; sulfuric acid;

DOI:10.1021/ja01538a050

upstream raw materials:

estradiol

2-chloro-5-nitrobenzophenone

Downstream raw materials:

2-(17β-acetoxy-2-hydroxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone

3-benzoyloxy-2-methoxyestra-1,3,5(10)-trien-17β-ol

(13S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl diacetate

2-(17β-hydroxy-2-methoxy-estra-1,3,5(10)-trien-3-yloxy)-5-nitro-benzophenone

Refernces