3-(4-METHOXYPHENOXY)PROPANOIC ACID

Base Information

• Chemical Name: 3-(4-METHOXYPHENOXY)PROPANOIC ACID
• CAS No.: 20811-60-3
• Molecular Formula: C10H12O4
• Molecular Weight: 196.203
• Hs Code.: 2918999090
• Mol file: 20811-60-3.mol

Synonyms:Propionic acid,3-(p-methoxyphenoxy)- (6CI,7CI,8CI);3-(4-Methoxyphenoxy)propionic acid;NSC153948;

Chemical Property of 3-(4-METHOXYPHENOXY)PROPANOIC ACID

Chemical Property:

• Vapor Pressure: 0.000121mmHg at 25°C
• Melting Point: 110.5 °C
• Refractive Index: 1.523
• Boiling Point: 321.7 °C at 760 mmHg
• PKA: 4.14±0.10(Predicted)
• Flash Point: 125.6 °C
• PSA: 55.76000
• Density: 1.188 g/cm³
• LogP: 1.54870
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Methoxyphenoxy)propanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 3-(4-METHOXYPHENOXY)PROPANOIC ACID

There total 9 articles about 3-(4-METHOXYPHENOXY)PROPANOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-Methoxyphenoxy)cyanoethane (63815-39-4) → 3-(4-methoxyphenoxy)propanoic acid (20811-60-3)

Guidance literature:

With hydrogenchloride; In water; at 90 ℃; for 3h;

DOI:10.1016/j.bmcl.2021.128269

Reference yield: 73.0%

chloropropionic acid (107-94-8) + 4-methoxy-phenol (150-76-5) → 3-(4-methoxyphenoxy)propanoic acid (20811-60-3)

Guidance literature:

With potassium hydroxide; sodium hydrogencarbonate; for 3h; Heating;

DOI:10.1021/jm00346a012

Reference yield: 30.0%

3-Bromopropionic acid (590-92-1) + 4-methoxy-phenol (150-76-5) → 3-(4-methoxyphenoxy)propanoic acid (20811-60-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1016/j.bmc.2005.11.031

upstream raw materials:

β-Propiolactone

sodium 4-methoxyphenolate

4-methoxy-phenol

2-(4-Methoxyphenoxy)cyanoethane

Downstream raw materials:

3-(4-Methoxy-phenoxy)-thiopropionic acid S-tert-butyl ester

6-methoxy-3,4-dihydrocoumarin

N-[2-hydroxy-2-(2,3-dihydrobenzo[β][1,4]dioxin-6-yl)-1-pyrrolidin-1-ylmethyl-ethyl]-3-(4-methoxy-phenoxy)-propionamide L-tartrate

N-[2-hydroxy-2-(2,3-dihydrobenzo[β][1,4]dioxin-6-yl)-1-pyrrolidin-1-ylmethyl-ethyl]-3-(4-methoxy-phenoxy)-propionamide

Refernces

• 1、 Begum, Ayisha F.,Balasubramanian, Kalpattu K.,Shanmugasundaram, Bhagavathy. "Acid activated montmorillonite K-10 mediated intramolecular acylation: Simple and convenient synthesis of 4-chromanones". supporting information. . Retrieved 2021/09/13.
• 2、 -. "METHOD OF TREATING POLYCYSTIC KIDNEY DISEASES WITH CERAMIDE DERIVATIVES". Paragraph 0182; 0183. . Retrieved 2016/10/08.