Technology Process of (-)-(2S)-2-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroquinoline
There total 29 articles about (-)-(2S)-2-[2-(3,4-dimethoxyphenyl)ethyl]-1,2,3,4-tetrahydroquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
bis(1,5-cyclooctadiene)diiridium(I) dichloride; (S)-6,6'-bis(diphenylphosphino)-1,1'-biphenyl-2,2'-diylbis(trifluoromethylsulfonate); hydrogen; iodine;
In
tetrahydrofuran;
at 20 ℃;
for 22h;
under 36201.3 Torr;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
Autoclave;
DOI:10.1055/s-0030-1260129
- Guidance literature:
-
With
chloro(1,5-cyclooctadiene)rhodium(I) dimer; ZhaoPhos; hydrogen;
In
dichloromethane; isopropyl alcohol;
at 25 ℃;
for 48h;
under 30402 Torr;
enantioselective reaction;
DOI:10.1039/c5sc04712a
- Guidance literature:
-
With
triethylsilane; trifluoroacetic acid;
at 20 ℃;
for 24h;
optical yield given as %ee;
Inert atmosphere;
DOI:10.1016/j.tetasy.2009.03.037