4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide

Base Information

• Chemical Name: 4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide
• CAS No.: 188108-07-8
• Molecular Formula: C₃₁H₃₁NO₃
• Molecular Weight: 465.592
• Mol file: 188108-07-8.mol

Synonyms:4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide

Chemical Property of 4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide

There total 2 articles about 4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4,4-bis(4-hydroxyphenyl)valeric acid (126-00-1) + 1,1'-carbonyldiimidazole (530-62-1) + dibenzylamine (103-49-1) → 4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide (188108-07-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

4,4-bis(4-hydroxyphenyl)valeric acid (126-00-1) + dibenzylamine (103-49-1) → 4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide (188108-07-8)

Guidance literature:

With 1,1'-carbonyldiimidazole; Yield given; Multistep reaction; 1.) THF, reflux, 2.) THF, reflux;

DOI:10.1016/S0960-894X(99)00404-7

Reference yield: 95.0%

4,4-Bis-(4-hydroxyphenyl)pentanoic acid dibenzylamide (188108-07-8) → 4,4'-[4-[Bis(phenylmethyl)amino]-1-methylbutylidene]-bisphenol (188108-09-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0960-894X(99)00404-7

upstream raw materials:

4,4-bis(4-hydroxyphenyl)valeric acid

dibenzylamine

1,1'-carbonyldiimidazole

Downstream raw materials:

4,4'-[4-[Bis(phenylmethyl)amino]-1-methylbutylidene]-bisphenol

Refernces

• 1、 Schelkun, Robert M.,Yuen, Po-wai,Malone, Thomas C.,Rock, David M.,Stoehr, Sally,Szoke, Balazs,Tarczy-Hornoch, Katalin. "Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)- methanes as N-type calcium channel blockers". . p. 2447 - 2452. Retrieved 2007/10/03.