Naphthalazine

Base Information

• Chemical Name: Naphthalazine
• CAS No.: 2144-00-5
• Molecular Formula: C22H16 N2
• Molecular Weight: 308.382
• Hs Code.: 2928000090
• European Community (EC) Number: 218-403-7
• NSC Number: 80714
• Mol file: 2144-00-5.mol

Synonyms:Naphthalazine;1-Naphthaldehyde, azine;1-Naphthalenecarboxaldehyde, (1-naphthalenylmethylene)hydrazone;SCHEMBL11342221;NSC80714;EINECS 218-403-7;NSC 80714;NSC-80714;Naphthalene-1-carbaldehyde (1-naphthylmethylene)hydrazone;Naphthalene-1-carbaldehyde(1-naphthylmethylene)hydrazone;1-Naphthalenecarboxaldehyde, 2-(1-naphthalenylmethylene)hydrazone

Chemical Property of Naphthalazine

Chemical Property:

• Vapor Pressure: 1.29E-09mmHg at 25°C
• Boiling Point: 499.3°Cat760mmHg
• Flash Point: 248.8°C
• PSA: 24.72000
• Density: 1.09g/cm³
• LogP: 5.44600
• XLogP3: 5.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 308.131348519
• Heavy Atom Count: 24
• Complexity: 413

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2C=NN=CC3=CC=CC4=CC=CC=C43
• Isomeric SMILES: C1=CC=C2C(=CC=CC2=C1)/C=N/N=C/C3=CC=CC4=CC=CC=C34

Technology Process of Naphthalazine

There total 11 articles about Naphthalazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-methyl-N'-(naphthalen-1-ylmethylene)benzenesulfonohydrazide (19350-73-3) → bis-[1]naphthylmethylene-hydrazine (2144-00-5)

Guidance literature:

With caesium carbonate; In acetonitrile; at 100 ℃; for 6h; Sealed tube;

DOI:10.1007/s11164-016-2688-3

Reference yield: 89.0%

1-naphthaldehyde (66-77-3) → bis-[1]naphthylmethylene-hydrazine (2144-00-5)

Guidance literature:

With hydrazine hydrate; In methanol; Ambient temperature;

Reference yield: 70.0%

naphthalene (91-20-3,71998-51-1,72931-45-4) + N,N,N',N'-tetraformylhydrazine (52023-52-6) → bis-[1]naphthylmethylene-hydrazine (2144-00-5)

Guidance literature:

With aluminium trichloride; In chlorobenzene; at 20 ℃; for 17h;

upstream raw materials:

1-naphthaldehyde

1-Cyanonaphthalene

1,1,1-Trichloro-2,2,2-trifluoroethane

naphthalen-1-ylmethylene-hydrazone

Downstream raw materials:

1-naphthaldehyde

(3-oxo-1,3-dihydroisobenzofuran-1-yl)acetic acid

1-naphthalenecarboxylic acid

Refernces

• 1、 Gunanathan, Chidambaram,Pradhan, Subham,Thiyagarajan, Subramanian. "Ruthenium(ii)-catalysed 1,2-selective hydroboration of aldazines". supporting information. p. 7147 - 7151. Retrieved 2021/08/30.
• 2、 Mahmoud,El-Bordany,Hassan,El-Azm, F. S. M. Abu. "Utility of nitriles in synthesis of pyrido[2,3-d]pyrimidines, thiazolo[3,2-a]pyridines, pyrano[2,3-b]benzopyrrole, and pyrido[2,3-d] benzopyrroles". . p. 2507 - 2521. Retrieved 2008/03/13.