Technology Process of 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethyl-N-[(2S)-piperidin-2-ylmethyl]imidazo[1,2-a]pyridine-3-carboxamide
There total 8 articles about 8-[(2,6-difluorobenzyl)oxy]-2,6-dimethyl-N-[(2S)-piperidin-2-ylmethyl]imidazo[1,2-a]pyridine-3-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; HATU;
In
N,N-dimethyl-formamide;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: ethanol / 72 h / Inert atmosphere; Molecular sieve; Reflux
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane / 8 h / Inert atmosphere; Reflux
3: hydrogen; palladium 10% on activated carbon / ethanol; water; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere
4: caesium carbonate / N,N-dimethyl-formamide / 5 h / 60 °C
5: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C
6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); palladium 10% on activated carbon; water; hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: water; lithium hydroxide / methanol; tetrahydrofuran / 16 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C
With
water; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;