(RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate

Base Information

• Chemical Name: (RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate
• CAS No.: 1393112-51-0
• Molecular Formula: C₂₀H₂₅NO₃S
• Molecular Weight: 359.489
• Mol file: 1393112-51-0.mol

Synonyms:(RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate

Chemical Property of (RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate

There total 1 articles about (RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine (56583-58-5,76985-10-9,58438-04-3) → (RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate (1393112-51-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.33 h / 0 °C

2: dichloromethane / 1 h

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 40 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; isopropyl alcohol;

DOI:10.1016/j.tetasy.2012.06.020

Reference yield: 93.4%

(RS)-S-ethyl 2-(tert-butoxycarbonylamino)-3-(naphthalen-2-yl)propanethioate (1393112-51-0) → C20H25NO3S + N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine (56583-58-5,76985-10-9,58438-04-3)

Guidance literature:

With alcalase CLEA; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tert-butyl alcohol; at 37 ℃; for 696h; optical yield given as %ee; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.tetasy.2012.06.020

upstream raw materials:

N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine

Downstream raw materials:

N-tert-butoxycarbonyl-3-(2-naphthyl)-L-alanine

Refernces