(6-fluoropyridin-3-yl)methyl methanesulphonate

Base Information

• Chemical Name: (6-fluoropyridin-3-yl)methyl methanesulphonate
• CAS No.: 864758-11-2
• Molecular Formula: C₇H₈FNO₃S
• Molecular Weight: 205.21
• Mol file: 864758-11-2.mol

Synonyms:(6-fluoropyridin-3-yl)methyl methanesulphonate

Chemical Property of (6-fluoropyridin-3-yl)methyl methanesulphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-fluoropyridin-3-yl)methyl methanesulphonate

There total 1 articles about (6-fluoropyridin-3-yl)methyl methanesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6-fluoropyridin-3-yl)methanol (39891-05-9) + methanesulfonyl chloride (124-63-0) → (6-fluoropyridin-3-yl)methyl methanesulphonate (864758-11-2)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 0.0833333h;

Reference yield: 45.0%

(6-fluoropyridin-3-yl)methyl methanesulphonate (864758-11-2) + 4-hydroxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one (864757-78-8) → 4-[(6-Fluoro-3-pyridinyl)methoxy]-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one

Guidance literature:

4-hydroxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

(6-fluoropyridin-3-yl)methyl methanesulphonate; In N,N-dimethyl-formamide; at 20 - 80 ℃;

With sodium hydrogencarbonate; In water; N,N-dimethyl-formamide;

Reference yield:

(6-fluoropyridin-3-yl)methyl methanesulphonate (864758-11-2) + 5-chloro-2-methoxy-N-(5-methylthiazol-2-yl)benzamide (805277-47-8) → 5-chloro-N-[(2Z)-3-[(6-fluoropyridin-3-yl)methyl]-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide (1187464-93-2)

Guidance literature:

5-chloro-2-methoxy-N-(5-methylthiazol-2-yl)benzamide; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

(6-fluoropyridin-3-yl)methyl methanesulphonate; In tetrahydrofuran; N,N-dimethyl-formamide; at 75 ℃; for 12h;

upstream raw materials:

(6-fluoropyridin-3-yl)methanol

methanesulfonyl chloride

Downstream raw materials:

5-chloro-N-[(2Z)-3-[(6-fluoropyridin-3-yl)methyl]-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide

Refernces

• 1、 -. "NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS". Page/Page column 27. . Retrieved 2009/10/06.